新冠后持续性头痛：905 例患者的多中心 9 个月随访研究。

Post-COVID-19 persistent headache: A multicentric 9-months follow-up study of 905 patients.

机构信息

Hospital Clinico Universitario de Valladolid, Headache Unit, Department of Neurology, Valladolid, Spain.

Department of Neurology, Hospital General de Albacete, Albacete, Spain.

出版信息

Cephalalgia. 2022 Jul;42(8):804-809. doi: 10.1177/03331024211068074. Epub 2022 Feb 15.

DOI:10.1177/03331024211068074

PMID:35166156

Abstract

BACKGROUND

Headache is a frequent symptoms of coronavirus disease 2019 (COVID-19). Its long-term evolution remains unknown. We aim to evaluate the long-term duration of headache in patients that presented headache during the acute phase of COVID-19.

METHODS

This is a post-hoc multicenter ambisective study including patients from six different third-level hospitals between 1 March and 27 April 2020. Patients completed 9 months of neurological follow-up.

RESULTS

We included 905 patients. Their median age was 51 (IQR 45-65), 66.5% were female, and 52.7% had a prior history of primary headache. The median duration of headache was 14 (6-39) days; however, the headache persisted after 3 months in 19.0% (95% CI: 16.5-21.8%) and after 9 months in 16.0% (95% confidence interval: 13.7-18.7%). Headache intensity during the acute phase was associated with a more prolonged duration of headache (Hazard ratio 0.655; 95% confidence interval: 0.582-0.737).

CONCLUSION

The median duration of headache was 2 weeks, but in approximately a fifth of patients it became persistent and followed a chronic daily pattern.

摘要

背景

头痛是 2019 冠状病毒病（COVID-19）的常见症状。其长期演变仍不清楚。我们旨在评估在 COVID-19 急性期出现头痛的患者头痛的长期持续时间。

方法

这是一项在后设、多中心、前瞻性研究，纳入了 2020 年 3 月 1 日至 4 月 27 日来自六家不同三级医院的患者。患者完成了 9 个月的神经学随访。

结果

我们纳入了 905 例患者。其平均年龄为 51 岁（四分位距 45-65），66.5%为女性，52.7%有原发性头痛病史。头痛的中位持续时间为 14 天（6-39）；然而，19.0%（95%可信区间：16.5-21.8%）的患者头痛持续 3 个月以上，16.0%（95%置信区间：13.7-18.7%）的患者头痛持续 9 个月以上。急性期头痛的强度与头痛持续时间较长相关（风险比 0.655；95%可信区间：0.582-0.737）。