Department of Cardiac Surgery, Fujian Branch of Shanghai Children's Medical Center, Fuzhou, China.
Fujian Children's Hospital, Fuzhou, China.
Anal Methods. 2022 Mar 3;14(9):900-906. doi: 10.1039/d1ay02192c.
Benzocaine (BZC) is a local anaesthetic drug coupled with numerous adverse effects, and thus poses a great challenge for its simple and highly sensitive detection. For resolving this issue, hydroxypropyl-β-cyclodextrin-carbon black (HP-β-CD-CB) nanohybrid that possesses the collaborative advantages of CB (, excellent electrical properties, large surface area) and HP-β-CD (, high molecule recognition and preconcentration capability) was synthesized in this study a simple process and then utilized as a novel electrode material to electrochemically detect BZC. With the optimized experimental conditions, the HP-β-CD-CB nanohybrid-modified electrode shows wide linearity from 0.05 to 7.0 μM and very low detection limit (0.015 μM) for BZC detection. In addition, the repeatability, stability, and selectivity as well as practical-sample analysis of the HP-β-CD-CB electrode were investigated, and the observed results are desirable. The superior sensing performances coupled with its advantages including low-cost, simple and highly sensitive detection suggest that HP-β-CD-CB has important potential application for BZC analysis in practical samples.
苯佐卡因（BZC）是一种局部麻醉药物，具有许多不良反应，因此对其进行简单、高灵敏度的检测提出了巨大挑战。为了解决这个问题，本研究通过简单的过程合成了具有 CB（良好的电学性能、大表面积）和 HP-β-CD（高分子识别和预富集能力）协同优势的羟丙基-β-环糊精-碳黑（HP-β-CD-CB）纳米杂化体，并将其用作电化学检测 BZC 的新型电极材料。在优化的实验条件下，HP-β-CD-CB 纳米杂化体修饰电极对 BZC 的检测具有较宽的线性范围（0.05-7.0 μM）和非常低的检测限（0.015 μM）。此外，还对 HP-β-CD-CB 电极的重复性、稳定性和选择性以及实际样品分析进行了研究，观察到的结果是理想的。这种具有优越传感性能的电极，加上其低成本、简单和高灵敏度检测的优点，表明 HP-β-CD-CB 对于实际样品中 BZC 的分析具有重要的潜在应用价值。
