Agaplesion Diakonieklinikum Hamburg, Hamburg, Germany.
Surg Technol Int. 2022 May 19;40:61-66. doi: 10.52198/22.STI.40.WH1527.
We report our experience in patients who were treated with cold plasma wound therapy from 2016 to 2020. Thirty-six patients with a median age of 71 years (23 males, 13 females) were registered in a prospective database. The median follow up was six months. In 15 patients, their wounds were associated with peripheral arterial disease, and they received peripheral interventional or open revascularisation prior to cold plasma therapy. Seven patients had a chronic venous insufficiency and 3 diabetic patients had chronic wounds caused by polyneuropathy. One patient suffered from chronic lymphoid disease. The cause of the wound could not be identified in the remaining patients. Wound treatment was conducted in an outpatient setting, if possible. Four patients were lost during follow-up. Surgical debridement of the wound before cold plasma therapy began was necessary in 14 cases. Each patient received 1 to 3 cold plasma treatments a week; 2 patients were treated for 1 year and the remaining patients were treated for 4 to 11 weeks. There were no major amputations in the long-term follow-up. In 25 patients, the progress of the wound stopped and in 11 patients the wounds were closed at the end of the therapy. In conclusion, our results support the use of cold plasma in complex wounds. Causal therapy is mandatory. Further studies are necessary to evaluate the impact of supplemental modern wound treatment with cold plasma therapy.
我们报告了从 2016 年到 2020 年使用冷等离子体创面治疗的患者的经验。36 名中位年龄为 71 岁的患者（23 名男性，13 名女性）在一个前瞻性数据库中进行了登记。中位随访时间为 6 个月。在 15 名患者中，他们的伤口与外周动脉疾病有关，在接受冷等离子体治疗之前，他们接受了外周介入或开放性血运重建。7 名患者患有慢性静脉功能不全，3 名糖尿病患者因多发性神经病而患有慢性伤口。1 名患者患有慢性淋巴细胞疾病。其余患者的伤口原因无法确定。如果可能的话，在门诊进行伤口治疗。在随访期间有 4 名患者失访。在开始冷等离子体治疗之前，有 14 例需要对伤口进行外科清创。每位患者每周接受 1 至 3 次冷等离子体治疗；2 名患者治疗 1 年，其余患者治疗 4 至 11 周。在长期随访中没有发生重大截肢。在 25 名患者中，伤口的进展停止，在 11 名患者中，伤口在治疗结束时闭合。总之，我们的结果支持将冷等离子体应用于复杂伤口。因果治疗是强制性的。需要进一步的研究来评估补充现代冷等离子体治疗对伤口的影响。
