Sun Yangyang, Gu Wenxian, Wang Gengfang, Zhou Xiaoli
Department of Pathology, Changzhou No. 2 People's Hospital Affiliated with Nanjing Medical University, Changzhou, China.
Histol Histopathol. 2022 Jul;37(7):691-698. doi: 10.14670/HH-18-436. Epub 2022 Feb 15.
Mucinous micropapillary carcinoma (MMPC) is a unique subtype of breast cancer, and there is as yet no detailed report on the clinical characteristics of MMPC.
MMPC, pure mucinous breast carcinoma (PMBC), and invasive micropapillary carcinoma (IMPC) samples were enrolled simultaneously, and immunohistochemistry analysis was performed to explore the clinicopathological attributes of MMPC. Moreover, survival analyses of MMPC were performed among the MMPC, PMBC, and IMPC groups and within the MMPC group.
The results showed that MMPC demonstrated distinct pathological features and that vascular invasion and lymph node metastasis were two significant clinical attributes of MMPC. MMPC leads to a shorter survival time than PMBC but an increased survival time compared to IMPC, while the tumor-node-metastasis stage and lymph node metastasis were identified as two independent prognostic elements for disease-free survival in discerning the MMPC prognosis.
The gathered data implied that further understanding and classification of MMPC may provide better individualized therapeutic strategies for MMPC treatment.
黏液性微乳头癌（MMPC）是乳腺癌的一种独特亚型，目前尚无关于MMPC临床特征的详细报道。
同时纳入MMPC、纯黏液性乳腺癌（PMBC）和浸润性微乳头癌（IMPC）样本，并进行免疫组化分析以探究MMPC的临床病理特征。此外，在MMPC、PMBC和IMPC组之间以及MMPC组内对MMPC进行生存分析。
结果显示，MMPC具有独特的病理特征，血管侵犯和淋巴结转移是MMPC的两个重要临床特征。MMPC导致的生存时间比PMBC短，但与IMPC相比生存时间延长，而肿瘤-淋巴结-转移分期和淋巴结转移被确定为辨别MMPC预后时无病生存的两个独立预后因素。
收集的数据表明，对MMPC的进一步了解和分类可能为MMPC治疗提供更好的个体化治疗策略。
