Mwanza Research Centre, National Institute for Medical Research, Mwanza, Tanzania.
Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.
APMIS. 2022 Apr;130(4):230-239. doi: 10.1111/apm.13214. Epub 2022 Mar 1.
This study aimed to investigate sickle cell trait (SCT) associations with physical activity, markers of insulin secretion and resistance, and glucose among people living with HIV infection (PLWH), both antiretroviral therapy (ART) naive and experienced, and HIV-uninfected adults. This was a cross-sectional study conducted in Mwanza, Northwestern Tanzania. We used data of 668 participants attained from two sub-studies of CICADA study. Mean age was 40 (SD 11.5) years, 402 (61.7%) were females and 157 (24.1%) had SCT. PLWH were 422 (64.7%), of these, 80 (18.9%) were on ART. People with SCT had higher risk of having an isolated β-cell dysfunction compared to those without SCT (RRR = 1.82, CI: 1.10, 3.01, p = 0.02). People with SCT but without HIV infection had lower average acceleration on the trunk longitudinal axis (ACCx) and higher level of self-reported physical activity. 30 min oral glucose tolerance test among PLWH on ART was higher in those with SCT compared to those without SCT. People with SCT are at higher risk of having β-cell dysfunction and those with SCT on ART are at more risk of developing diabetes. Future studies to investigate the interaction between SCT and HIV/ART on risk of diabetes should be considered.
本研究旨在探讨镰状细胞特征（SCT）与身体活动、胰岛素分泌和抵抗标志物以及 HIV 感染人群（PLWH）和未感染 HIV 的成年人的葡萄糖之间的关系，这些人群无论是否接受过抗逆转录病毒治疗（ART）。这是在坦桑尼亚西北部姆万扎进行的一项横断面研究。我们使用了 CICADA 研究的两个子研究中获得的 668 名参与者的数据。平均年龄为 40 岁（SD 11.5），402 名（61.7%）为女性，157 名（24.1%）有 SCT。PLWH 为 422 名（64.7%），其中 80 名（18.9%）正在接受 ART。与没有 SCT 的人相比，有 SCT 的人发生孤立β细胞功能障碍的风险更高（RRR=1.82，CI：1.10，3.01，p=0.02）。没有 HIV 感染但有 SCT 的人在躯干纵向轴上的平均加速度（ACCx）较低，自我报告的身体活动水平较高。接受 ART 的 PLWH 的 30 分钟口服葡萄糖耐量试验中，有 SCT 的人比没有 SCT 的人更高。有 SCT 的人发生β细胞功能障碍的风险更高，而接受 ART 的有 SCT 的人发生糖尿病的风险更高。应考虑开展未来研究，以调查 SCT 和 HIV/ART 之间的相互作用对糖尿病风险的影响。
