Department of Pharmacology, Universidade Federal de São Paulo, Escola Paulista de Medicina, Laboratory of Autonomic and Cardiovascular Pharmacology, 55 11 5576-4973, Rua Pedro de Toledo, 669, Vila Clementino, São Paulo, SP, Brazil.
Curr Cancer Drug Targets. 2022;22(5):351-360. doi: 10.2174/1568009622666220215143805.
The hypothesis that hypertension is clinically associated with an enhanced risk of developing cancer has been highlighted. However, the working principles involved in this link are still under intensive discussion. A correlation among inflammation, hypertension, and cancer could accurately describe the clinical link between these diseases. In addition, dyshomeostasis of Ca has been considered to be involved in both cancer and hypertension, and inflammation. There is a strong link between Ca signalling, e.g. enhanced Ca signals, and inflammatory outcomes. cAMP also modulates pro- and anti-inflammatory outcomes; pharmaceuticals, which increase intracellular cAMP levels, can decrease the production of proinflammatory mediators and enhance the production of antiinflammatory outcomes.
This article highlights the participation of Ca/cAMP signalling in the clinical association among inflammation, hypertension, and an enhanced risk for the development of cancer. In addition, considering that research on coronavirus disease 2019 (COVID-19) is a rapidly evolving field, this article also reviews recent reports related to the role of Ca channel blockers in restoring Ca signalling disruption due to COVID-19, including the relationship among COVID-19, cancer, and hypertension.
An understanding of the association among these diseases could expand current pharmacotherapy, involving Ca channel blockers and pharmaceuticals that facilitate a rise in cAMP levels.
高血压与癌症风险增加之间存在临床关联的假设已被强调。然而，这一联系中涉及的工作原理仍在深入讨论中。炎症、高血压和癌症之间的相关性可以准确描述这些疾病之间的临床联系。此外，钙的动态平衡失调被认为与癌症和高血压以及炎症有关。钙信号（例如增强的钙信号）与炎症结果之间存在强烈联系。cAMP 还调节促炎和抗炎结果；增加细胞内 cAMP 水平的药物可以减少促炎介质的产生并增强抗炎结果的产生。
本文强调了 Ca/cAMP 信号在炎症、高血压和癌症发展风险增加之间的临床关联中的作用。此外，鉴于对 2019 年冠状病毒病（COVID-19）的研究是一个快速发展的领域，本文还回顾了最近关于钙通道阻滞剂在 COVID-19 引起的钙信号紊乱恢复中的作用的报告，包括 COVID-19、癌症和高血压之间的关系。
对这些疾病之间的关联的理解可以扩展当前的药物治疗，包括钙通道阻滞剂和促进 cAMP 水平升高的药物。
