Medicinal and Natural Product Laboratory, Department of Chemistry, Chandigarh University, Gharuan-140413, Mohali, Punjab, India.
Anticancer Agents Med Chem. 2022 Aug 4;22(15):2715-2725. doi: 10.2174/1871520622666220215122756.
Selenium nanoparticles (SeNPs) have gained a place in the biomedical field; they serve as chemotherapeutic agents for targeted drug delivery due to their capacity to exert distinct mechanisms of action on cancer and normal cells. The principle behind these mechanisms is the generation of reactive oxygen species (ROS), which accelerates apoptosis via the dysfunction of various pathways. SeNPs, when used in higher concentrations, induce toxicity; however, conjugation and surface functionalization are some techniques available to ameliorate their toxic nature as well as enhance their anticancer activity.
The primary goal of this analysis is to provide a thorough and systematic investigation into the use of various SeNPs in localized drug targeting for cancer therapy. This has been achieved by citing examples of numerous SeNPs and their use as a drug targeting agent for cancer therapy.
All relevant data and information about the various SeNPs for drug targeting in cancer therapy were gathered from various databases, including Science Direct, PubMed, Taylor and Francis imprints, American Chemical Society, Springer, Royal Society of Chemistry, and Google Scholar.
SeNPs are explored due to their better biopharmaceutical properties and cytostatic behavior. Se, as an essential component of the enzyme glutathione peroxidase (GPx) and other seleno-chemical substances, might boost chemotherapeutic efficacy and protect tissues from cellular damage caused by ROS. SeNPs have the potential to set the stage for developing new strategies to treat malignancy.
This review extensively analyzed the anticancer efficacy and functionalization strategies of SeNPs in drug delivery to cancer cells. In addition, this review highlights the mechanism of action of drug-loaded SeNPs to suppress the proliferation of cancer cells in different cell lines.
硒纳米粒子（SeNPs）在生物医药领域占有一席之地；由于它们对癌细胞和正常细胞具有不同的作用机制，因此可作为靶向药物递送的化疗药物。这些机制的原理是产生活性氧（ROS），通过各种途径的功能障碍加速细胞凋亡。当使用更高浓度的 SeNPs 时，会诱导毒性；然而，缀合和表面功能化是一些可改善其毒性并增强其抗癌活性的技术。
本分析的主要目的是全面系统地研究各种 SeNPs 在癌症治疗局部药物靶向中的应用。这是通过引用许多 SeNPs 的例子及其作为癌症治疗药物靶向剂的应用来实现的。
从包括 Science Direct、PubMed、Taylor and Francis imprints、美国化学学会、Springer、皇家化学学会和 Google Scholar 在内的各种数据库中收集了有关各种用于癌症治疗药物靶向的 SeNPs 的所有相关数据和信息。
由于其更好的生物制药特性和细胞抑制行为，研究了 SeNPs。作为谷胱甘肽过氧化物酶（GPx）和其他硒化学物质等酶的必需成分的 Se，可能会提高化疗效果并保护组织免受 ROS 引起的细胞损伤。SeNPs 有可能为开发治疗恶性肿瘤的新策略奠定基础。
本综述广泛分析了 SeNPs 在抗癌药物中的抗癌功效和功能化策略。此外，本综述强调了载药 SeNPs 抑制不同细胞系中癌细胞增殖的作用机制。
