胸膜转移性黏液表皮样癌：一例报告。

Metastatic mucoepidermoid carcinoma to the pleura: a case report.

机构信息

Department of Pathology and Laboratory Medicine,, University of Nebraska Medical Center, Omaha, NE, USA.

Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL, 32610, USA.

出版信息

J Med Case Rep. 2022 Feb 16;16(1):69. doi: 10.1186/s13256-022-03285-y.

DOI:10.1186/s13256-022-03285-y

PMID:35168684

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8848957/

Abstract

BACKGROUND

Mucoepidermoid carcinoma is the most common malignant neoplasm arising from the salivary glands (Ali et al. in J Ayub Med Coll Abbottabad 20(2): 141-2, 2008, Xi et al. in World J Surg Oncol 10: 232, 2012). When arising from anatomic sites other than the salivary glands it can be a diagnostic challenge. Primary and metastatic mucoepidermoid carcinoma from and to the pleura are extremely rare entities that are frequently misdiagnosed as adenocarcinoma, adenosquamous carcinoma, or squamous cell carcinoma (Xi et al. in World J Surg Oncol 10: 232, 2012).

CASE PRESENTATION

We describe an unusual case of a 64-year-old Caucasian female patient with metastatic high-grade mucoepidermoid carcinoma to the pleura, morphologically resembling squamous cell carcinoma. Molecular studies of both the parotid gland and pleural tumors helped prove the metastatic nature of the pleural lesion.

CONCLUSIONS

Metastatic mucoepidermoid carcinoma to the pleura is a rare entity, frequently misdiagnosed as squamous cell carcinoma. Differentiating between a lung primary and a metastatic disease has treatment implications and prognostic significance for the patient. When morphologic and immunophenotypic overlap exists, molecular testing can help distinguish mucoepidermoid carcinoma from other neoplasms.

摘要

背景

黏液表皮样癌是最常见的源自唾液腺的恶性肿瘤（Ali 等人，2008 年，在《阿尤布医学院学报 Abbottabad》第 20 卷第 2 期第 141-2 页；Xi 等人，2012 年，在《世界外科肿瘤学杂志》第 10 卷第 232 页）。当它起源于唾液腺以外的解剖部位时，可能会成为一个诊断挑战。原发和转移性来自和转移到胸膜的黏液表皮样癌是非常罕见的实体，经常被误诊为腺癌、腺鳞癌或鳞状细胞癌（Xi 等人，2012 年，在《世界外科肿瘤学杂志》第 10 卷第 232 页）。