School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, Guangdong, 518060, PR China.
Shenzhen Refresh Intelligent Technology Co.,Ltd. Shenzhen, Guangdong, 518000, PR China.
Anal Chim Acta. 2022 Mar 8;1197:339526. doi: 10.1016/j.aca.2022.339526. Epub 2022 Jan 20.
The portable electrochemical platform can adapt to more usage scenarios, which is essential for drug discovery, toxicology, and cell biology. Here, we constructed the wireless USB-like electrochemical platform for simultaneous multi-channel electrochemical sensing in microdroplet array. On such platform, multi-channel mini-pillar arrays can anchor reagent droplet (a few microliters to dozens of microliters), and the wireless USB-like electrochemical platform can achieve simultaneously multi-channel detection. As a concept-of-proof for multi-channel, the 4∗4 channels are chosen as a model to proof the practicality of such portable electrochemical platform, the relative standard deviation (RSD) of such a platform in microdroplets sensing is below 5% level. The quantitative electrochemical analysis of multiple glucose concentrations in miniature workstation was also achieved, and only 0.97% difference between traditional electrochemical workstation. The wireless USB-like electrochemical platform with the characteristics of cloud data management and multi-channel, which enables remote detection and analysis and presents an opportunity for future portable high-throughput biomedical applications.
该便携式电化学平台可适应更多的使用场景,这对药物发现、毒理学和细胞生物学至关重要。在这里,我们构建了用于微滴阵列中同时多通道电化学传感的无线 USB 样电化学平台。在该平台上,多通道迷你柱阵列可以固定试剂液滴(数微升至数十微升),而无线 USB 样电化学平台可以实现同时多通道检测。作为多通道的概念验证,选择 4*4 通道作为模型来证明这种便携式电化学平台的实用性,该平台在微滴检测中的相对标准偏差(RSD)低于 5%。还实现了微型工作站中多个葡萄糖浓度的定量电化学分析,与传统电化学工作站相比仅相差 0.97%。这种具有云数据管理和多通道功能的无线 USB 样电化学平台,可实现远程检测和分析,为未来的便携式高通量生物医学应用提供了机会。