Zhejiang University, Hangzhou, 310058, Zhejiang, China; Research Center for Industries of the Future, Westlake University, Hangzhou, Zhejiang, 310030, China.
Research Center for Industries of the Future, Westlake University, Hangzhou, Zhejiang, 310030, China.
Anal Chim Acta. 2023 Mar 1;1244:340860. doi: 10.1016/j.aca.2023.340860. Epub 2023 Jan 23.
In the context of globalization, individuals have an increased chance of being infected by multiple viruses simultaneously, thereby highlighting the importance of developing multiplexed devices. In addition to sufficient sensitivity and rapid response, multi-virus sensing techniques are expected to offer additional advantages including high throughput, one-time sampling for parallel analysis, and full automation with data visualization. In this paper, we review the optical, electrochemical, and mechanical platforms that enable multi-virus biosensing. The working mechanisms of each platform, including the detection principle, transducer configuration, bio-interface design, and detected signals, are reviewed. The advantages and limitations, as well as the challenges in implementing various detection strategies in real-life scenarios, were evaluated. Future perspectives on multiplexed biosensing techniques are critically discussed. Earlier access to multi-virus biosensors will efficiently serve for immediate pandemic control, such as in emerging SARS-CoV-2 and monkeypox cases.
在全球化的背景下，个体感染多种病毒的可能性增加，因此开发多重检测设备至关重要。除了足够的灵敏度和快速响应外，多病毒传感技术还应具有其他优势，包括高通量、一次采样并行分析，以及具有数据可视化的全自动化。本文综述了用于多病毒生物传感的光学、电化学和机械平台。综述了每个平台的工作机制，包括检测原理、换能器配置、生物界面设计和检测信号。评估了各种检测策略在实际场景中的优缺点和挑战。批判性地讨论了多重生物传感技术的未来展望。尽早获得多病毒生物传感器将有助于高效地进行即时大流行控制，例如在 SARS-CoV-2 和猴痘等新出现的病例中。
