乳酸在肿瘤和免疫环境中的非常规作用。
Unconventional roles of lactate along the tumor and immune landscape.
作者信息
Ippolito Luigi, Sonveaux Pierre, Chiarugi Paola
机构信息
Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.
Pole of Pharmacology and Therapeutics, Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain (UCLouvain), Brussels, Belgium.
出版信息
Trends Endocrinol Metab. 2022 Apr;33(4):231-235. doi: 10.1016/j.tem.2022.01.005. Epub 2022 Feb 12.
The tumor ecosystem evolves with dynamic interactions between cancer and normal cells, and nutrients have emerged as new regulators of cancer hallmarks. Lactate has climbed the rankings as a multifunctional molecule orchestrating many aspects of the disease onset and progression. Here, we patchwork and discuss the main recent findings conferred during the EMBO workshop titled 'Lactate: Unconventional Roles of a Nutrient Along the Tumor Landscape.'
肿瘤生态系统随着癌细胞与正常细胞之间的动态相互作用而演变，营养素已成为癌症特征的新调节因子。乳酸作为一种多功能分子，在疾病的发生和发展的许多方面发挥作用，其地位日益重要。在此，我们梳理并讨论了在题为“乳酸：肿瘤环境中营养素的非常规作用”的欧洲分子生物学组织研讨会上提出的主要最新研究成果。
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