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Human CD34 very small embryonic-like stem cells can give rise to endothelial colony-forming cells with a multistep differentiation strategy using UM171 and nicotinamide acid.

作者信息

Domingues Alison, Rossi Elisa, Bujko Kamila, Detriche Grégoire, Richez Ulysse, Blandinieres Adeline, Kucia Magdalena, Ratajczak Janina, Smadja David M, Ratajczak Mariusz Z

机构信息

Stem Cell Biology Program, University of Louisville, Louisville, KY, 40245, USA.

Université de Paris, INSERM, Innovative Therapies in Haemostasis, F-75006, Paris, France.

出版信息

Leukemia. 2022 May;36(5):1440-1443. doi: 10.1038/s41375-022-01517-0. Epub 2022 Feb 15.

DOI:10.1038/s41375-022-01517-0
PMID:35169243
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9061289/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d700/9061289/d5ccc978afe6/41375_2022_1517_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d700/9061289/d5ccc978afe6/41375_2022_1517_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d700/9061289/d5ccc978afe6/41375_2022_1517_Fig1_HTML.jpg

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Human CD34 very small embryonic-like stem cells can give rise to endothelial colony-forming cells with a multistep differentiation strategy using UM171 and nicotinamide acid.人类CD34+非常小的胚胎样干细胞可以利用UM171和烟酰胺酸，通过多步骤分化策略产生内皮集落形成细胞。
Leukemia. 2022 May;36(5):1440-1443. doi: 10.1038/s41375-022-01517-0. Epub 2022 Feb 15.
2
Correction: Human CD34 very small embryonic-like stem cells can give rise to endothelial colony-forming cells with a multistep differentiation strategy using UM171 and nicotinamide acid.更正：人CD34+非常小的胚胎样干细胞可通过使用UM171和烟酰胺酸的多步骤分化策略产生内皮集落形成细胞。
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CD34 hybrid cells promote endothelial colony-forming cell bioactivity and therapeutic potential for ischemic diseases.CD34 杂交细胞促进内皮细胞集落形成细胞的生物活性和治疗缺血性疾病的潜力。
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[Effect of Bmi1 gene overexpression on hematopoietic differentiation colony-forming assay of human embryonic stem cells].[Bmi1基因过表达对人胚胎干细胞造血分化集落形成试验的影响]
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本文引用的文献

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Development and Application of Endothelial Cells Derived From Pluripotent Stem Cells in Microphysiological Systems Models.多能干细胞来源的内皮细胞在微生理系统模型中的开发与应用
Front Cardiovasc Med. 2021 Feb 15;8:625016. doi: 10.3389/fcvm.2021.625016. eCollection 2021.
2
Generation of Endothelial Cells From Human Pluripotent Stem Cells.人多能干细胞衍生的内皮细胞。
Arterioscler Thromb Vasc Biol. 2019 Jul;39(7):1317-1329. doi: 10.1161/ATVBAHA.119.312265. Epub 2019 May 9.
3
Standardization of methods to quantify and culture endothelial colony-forming cells derived from peripheral blood: Position paper from the International Society on Thrombosis and Haemostasis SSC.
免疫特权的脐带血来源内皮祖细胞：推动免疫调节和血管再生
Angiogenesis. 2025 Mar 6;28(2):19. doi: 10.1007/s10456-025-09973-9.
4
models of leukemia development: the role of very small leukemic stem-like cells in the cellular transformation cascade.白血病发展模型：极小的白血病干细胞样细胞在细胞转化级联反应中的作用
Front Cell Dev Biol. 2025 Jan 3;12:1463807. doi: 10.3389/fcell.2024.1463807. eCollection 2024.
5
Next-generation sequencing protocol of hematopoietic stem cells (HSCs). Step-by-step overview and troubleshooting guide.造血干细胞（HSCs）的下一代测序方案。逐步概述及故障排除指南。
PLoS One. 2025 Jan 9;20(1):e0313009. doi: 10.1371/journal.pone.0313009. eCollection 2025.
6
Endothelial heterogeneity in bone marrow: insights across development, adult life and leukemia.骨髓中的内皮异质性：发育、成年期及白血病中的见解
Leukemia. 2025 Jan;39(1):8-24. doi: 10.1038/s41375-024-02453-x. Epub 2024 Nov 11.
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Selected stem cell populations in pediatric acute lymphoblastic leukemia.小儿急性淋巴细胞白血病中的特定干细胞群体。
Front Immunol. 2024 Sep 25;15:1446687. doi: 10.3389/fimmu.2024.1446687. eCollection 2024.
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Murine and Human-Purified very Small Embryonic-like Stem Cells (VSELs) Express Purinergic Receptors and Migrate to Extracellular ATP Gradient.鼠源和人源纯化的极小胚胎样干细胞（VSELs）表达嘌呤能受体，并向细胞外 ATP 浓度梯度迁移。
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Stem Cell Rev Rep. 2018 Aug;14(4):510-524. doi: 10.1007/s12015-018-9821-1.
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Efficient and robust differentiation of endothelial cells from human induced pluripotent stem cells via lineage control with VEGF and cyclic AMP.通过VEGF和环磷酸腺苷进行谱系控制，从人诱导多能干细胞高效且稳健地分化内皮细胞。
PLoS One. 2017 Mar 13;12(3):e0173271. doi: 10.1371/journal.pone.0173271. eCollection 2017.
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Stem Cells. 2017 Apr;35(4):909-919. doi: 10.1002/stem.2577. Epub 2017 Mar 1.
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