Applied Midwifery, Master's Study Program of STIKes Dharma Husada, Bandung, West Java, Indonesia.
Doctoral Program of Medical Science, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, Indonesia.
Med Arch. 2021 Oct;75(5):335-339. doi: 10.5455/medarh.2021.75.335-339.
Measles outbreaks under high coverage of measles vaccination in Indonesia is gaining a necessary evaluation of factors associated with measles-vaccine immune responses.
The purposes of recent study were to evaluate the association of sociodemographic and anthropometric parameters and specific immune responses towards first dose Edmonston-Zagreb (EZ) measles vaccine in Indonesian infants.
A total of 35 infants were enrolled in this cohort study. Measles immune responses were followed up at one and six months after vaccination then analyzed for its association with sociodemographic, anthropometric, and nutritional parameters. The plaque-reduction microneutralization assay was conducted to measure the titer of measles specific IgG antibody. The level of CD4 and CD8 T-cells that exhibiting gamma interferon (IFN-γ) secretion were analyzed by flow cytometry. The association between variable was analyzed by linear regression. The difference immune response among variable were analyzed with Mann-Whitney test.
Vitamin A supplementation and breastfeeding were predicted as associated factor for humoral and cellular immune response after one month and six months measles vaccination among Indonesia Infants.
Nutritional factor is associated with measles vaccination immune response in Indonesian infants.
印度尼西亚麻疹疫苗高覆盖率下的麻疹暴发，需要对与麻疹疫苗免疫反应相关的因素进行必要评估。
本研究旨在评估社会人口学和人体测量参数以及对印度尼西亚婴儿首剂 Edmonston-Zagreb（EZ）麻疹疫苗的特定免疫反应与这些因素的相关性。
本队列研究共纳入 35 名婴儿。在接种疫苗后一个月和六个月时对麻疹免疫反应进行随访，然后分析其与社会人口学、人体测量和营养参数的相关性。采用蚀斑减少微量中和试验检测麻疹特异性 IgG 抗体滴度。采用流式细胞术分析分泌γ干扰素（IFN-γ）的 CD4 和 CD8 T 细胞水平。采用线性回归分析变量之间的相关性。采用 Mann-Whitney 检验分析各变量之间的免疫反应差异。
维生素 A 补充和母乳喂养被预测为印度尼西亚婴儿接种麻疹疫苗后一个月和六个月时体液和细胞免疫反应的相关因素。
营养因素与印度尼西亚婴儿麻疹疫苗免疫反应相关。
