Wallgren A, Arner O, Bergström J, Blomstedt B, Granberg P O, Räf L, Silfverswärd C, Einhorn J
Int J Radiat Oncol Biol Phys. 1986 Apr;12(4):533-7. doi: 10.1016/0360-3016(86)90060-x.
In a randomized trial, 960 women with Stage 1-3 operable breast cancer were treated by a modified radical mastectomy alone, or by the same procedure, preceded or followed by radiotherapy (4500 rad to the breast/chest wall, and internal mammary, axillary and supraclavicular lymph nodes). Up to ten years after treatment, there is an increasing gap between the recurrence-free survival of the irradiated patients and the surgical controls. Between the two types of radiotherapy, there was no difference. There were significantly fewer distant metastases and a tendency for improved survival in node positive patients treated with postoperative radiotherapy, compared to the surgical controls, this difference was, however, statistically not significant.
在一项随机试验中，960例1 - 3期可手术乳腺癌女性患者，一部分仅接受改良根治性乳房切除术，另一部分在相同手术基础上，术前或术后接受放疗（乳房/胸壁、内乳、腋窝及锁骨上淋巴结接受4500拉德照射）。治疗后长达十年，接受放疗患者的无复发生存率与手术对照组之间的差距不断增大。两种放疗方式之间无差异。与手术对照组相比，术后放疗的淋巴结阳性患者远处转移显著减少，且有生存改善的趋势，不过这种差异在统计学上不显著。
