Andrade Maria Margarida, Gorgulho Ana, Magalhães Rita Tinoco, Valadas Rita, Pereira Luís Miguel, Freire Sara, Cruz Diogo
Internal Medicine Department, Hospital de Cascais Dr. José de Almeida, Alcabideche, Portugal.
Faculty of Medicine, University of Lisbon, Lisbon, Portugal.
Eur J Case Rep Intern Med. 2022 Jan 17;9(1):003073. doi: 10.12890/2022_003073. eCollection 2022.
spp. human infection is endemic in Portugal in the form of Mediterranean spotted fever caused by subsp. and Israeli spotted fever (ISF) caused by subsp. . We describe a rare case of haemophagocytic lymphohistiocytosis (HLH) due to ISF, with atypical manifestations. We highlight the need for clinical suspicion for this diagnosis and the importance of timely intervention and support.
Haemophagocytic lymphohistiocytosis is a rare complication of rickettsiosis.An exuberant inflammatory reaction with multisystemic dysfunction should raise suspicion.Cutaneous and neurological manifestations can be serious and extensive.
立克次氏体在葡萄牙呈地方流行，以由康氏立克次氏体亚种引起的地中海斑疹热和由小蛛立克次氏体亚种引起的以色列斑疹热（ISF）的形式存在。我们描述了一例由ISF引起的噬血细胞性淋巴组织细胞增生症（HLH）罕见病例，具有非典型表现。我们强调对此诊断需临床怀疑，以及及时干预和支持的重要性。
噬血细胞性淋巴组织细胞增生症是立克次体病的一种罕见并发症。伴有多系统功能障碍的旺盛炎症反应应引起怀疑。皮肤和神经表现可能严重且广泛。
