乳香树来源的多样三萜类化合物及其抗炎活性。
Diverse Triterpenoids from Mastic Produced by Pistacia lentiscus and Their Anti-Inflammatory Activities.
机构信息
The Laboratory of Effective Substances of Jiangxi Genuine Medicinal Materials, College of Life Sciences, Jiangxi Normal University, Nanchang, 330022, China.
University and College Key Lab of Natural Product Chemistry and Application in Xinjiang, School of Chemistry and Environmental Science, Yili Normal University, Yi Li Ha Sa Ke Zi Zhi Zhou, Yining, 835000, China.
出版信息
Chem Biodivers. 2022 Mar;19(3):e202101012. doi: 10.1002/cbdv.202101012. Epub 2022 Feb 15.
Eight undescribed triterpenoids (1-8), including one apotirucallane-type triterpenoid (1), six tirucallane-type triterpenoids (2-7), and one oleanane-type triterpenoid (8), along with ten known compounds (9-18) were isolated from the resins of Pistacia lentiscus. Their structures were elucidated by integrating NMR spectroscopic analyses and ESI-HR-MS. Compounds 5, 11-17 exhibited moderate inhibitory abilities against NO production in LPS-induced RAW264.7 cells, with IC values in the range of 18.26-50.37 μM, compared to that of the positive control dexamethasone (IC =20.24 μM).
从黄连木树脂中分离得到了 8 种未被描述的三萜类化合物（1-8），包括 1 种阿波萜烷型三萜类化合物（1）、6 种三萜烷型三萜类化合物（2-7）和 1 种齐墩果烷型三萜类化合物（8），以及 10 种已知化合物（9-18）。通过 NMR 光谱分析和 ESI-HR-MS 的综合解析，确定了它们的结构。化合物 5、11-17 对 LPS 诱导的 RAW264.7 细胞中 NO 生成具有中等抑制能力，IC 值范围为 18.26-50.37 μM，与阳性对照地塞米松（IC =20.24 μM）相比。
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