School of Nutritional Sciences and Wellness, The University of Arizona, Tucson, AZ 85721, USA.
Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA.
Nutrients. 2024 Sep 2;16(17):2941. doi: 10.3390/nu16172941.
Chios mastic gum (CMG) is a resin obtained from the var. tree that grows in the Mediterranean. For millennia, it has been renowned for its medicinal properties, but recently, CMG has gained attention due to its pronounced anti-inflammatory and antioxidative properties and its use in oral health, inflammatory bowel disease, cancer, and risk factors related to cardiovascular and metabolic diseases. This narrative review seeks to briefly overview its bioactive constituents and examine and describe its potential as a cardiometabolic disease (CMD) phytotherapeutic. The results of clinical trials and in vivo, in vitro, and in silico studies provide accumulating evidence of the mechanisms underlying CMG's impacts on lipid and glucose metabolism, cardiovascular and hepatic health, inflammation, oxidative stress, body composition, and microbiota. Despite the relatively limited studies with mixed results, they have provided the foundation to understand the strengths, weaknesses, and opportunities moving forward that may help to establish CMG and its bioactives as viable therapeutics for CMD.
奇亚树胶（CMG）是从地中海生长的奇亚树的变种中提取的树脂。几千年来，它以其药用特性而闻名，但最近，由于其明显的抗炎和抗氧化特性，以及在口腔健康、炎症性肠病、癌症和心血管代谢疾病相关风险因素中的应用，CMG 引起了人们的关注。本综述旨在简要概述其生物活性成分，并研究和描述其作为一种心脏代谢疾病（CMD）植物疗法的潜力。临床试验以及体内、体外和计算机模拟研究的结果提供了越来越多的证据，证明了 CMG 对脂质和葡萄糖代谢、心血管和肝脏健康、炎症、氧化应激、身体成分和微生物组影响的机制。尽管这些研究相对有限，结果也各不相同，但它们为理解未来的优势、劣势和机遇提供了基础，这可能有助于将 CMG 及其生物活性物质确立为治疗 CMD 的可行疗法。
