Nyland Anja Nilsen, Nordtveit Elin Serine, Bosse Franziskus Johannes, Løes Sigbjørn
Tidsskr Nor Laegeforen. 2022 Feb 14;142(3). doi: 10.4045/tidsskr.21.0478. Print 2022 Feb 15.
Chronic non-bacterial osteomyelitis is an inflammatory bone disorder that may affect children and adolescents. Infections, malignancy and other differential diagnoses require consideration. Osteomyelitis of the jaw is a rare condition, but non-bacterial osteomyelitis is probably more common than previously thought, also in the mandible.
We present four paediatric cases with osteomyelitis of the jaw with no obvious infection source or fever, but mandibular swelling and pain. All the patients were examined clinically, and X-ray, MRI and bone biopsies were performed. Therapeutic measures involved antibiotics, surgical debridement, use of NSAIDS and in one case peroral steroids.
Even though all cases started with similar symptoms, the aetiology remained unclear and it was challenging to reach the final diagnosis. The possibility of chronic non-bacterial osteomyelitis was assessed late. The international nomenclature for osteomyelitis is not consistent, and it is in our opinion important to emphasise the aetiology of the condition to avoid terminology misinterpretations which may delay effective treatment.
慢性非细菌性骨髓炎是一种可能影响儿童和青少年的炎性骨病。需要考虑感染、恶性肿瘤及其他鉴别诊断。颌骨骨髓炎是一种罕见病症,但非细菌性骨髓炎可能比之前认为的更常见,在下颌骨也是如此。
我们报告4例颌骨骨髓炎的儿科病例,这些病例无明显感染源或发热症状,但有下颌肿胀和疼痛。所有患者均接受了临床检查,并进行了X线、磁共振成像(MRI)和骨活检。治疗措施包括使用抗生素、手术清创、使用非甾体抗炎药(NSAIDS),其中1例使用了口服类固醇。
尽管所有病例最初症状相似,但病因仍不明确,做出最终诊断具有挑战性。慢性非细菌性骨髓炎的可能性评估较晚。骨髓炎的国际命名并不一致,我们认为强调该病的病因很重要,以避免可能延误有效治疗的术语误解。