Hayashi H, Wake N, Ichinoe K, Nakamura K, Abe K, Sakashita S
Nihon Sanka Fujinka Gakkai Zasshi. 1986 Mar;38(3):289-97.
The development of teratomas and yolk sac tumors from displaced yolk sac is well documented in rats and mice. However, the precise mechanisms of induction and pathogeneses of these tumors still remain unknown. The present study was undertaken in order 1) to elucidate whether this phenomenon is common to all rodents, 2) to identify the origin of these tumors and 3) to explore specific chromosomal changes in yolk sac tumors. Ten benign teratomas and two malignant tumors with teratomatous elements were obtained from 33 Chinese hamsters after fetectomy, followed by displacement of yolk sac. The histological characteristics and the presence of laminin in the stroma suggested that the malignant tumors belonged to the category of yolk sac tumors. Similarities in electromicroscopic features observed in the tumor cells and the yolk sac of normal 12-day conceptuses suggested that the tumor originated from yolk sac cells. Chromosomal analyses of in vitro cell lines established from one of the yolk sac tumors disclosed that the tumors was composed of clones with an XX and XY sex chromosome constitution. The 1p + marker was identified as a consistent abnormality, which seemed to play an important role in the development of yolk sac tumors in Chinese hamsters.
在大鼠和小鼠中，移位的卵黄囊发育成畸胎瘤和卵黄囊瘤已有充分记录。然而，这些肿瘤的诱导和发病的确切机制仍然未知。本研究旨在：1）阐明这种现象是否在所有啮齿动物中都很常见；2）确定这些肿瘤的起源；3）探索卵黄囊瘤中的特定染色体变化。从33只中国仓鼠进行胎仔切除术后移位卵黄囊，获得了10个良性畸胎瘤和2个含有畸胎瘤成分的恶性肿瘤。组织学特征和基质中层粘连蛋白的存在表明，恶性肿瘤属于卵黄囊瘤类别。肿瘤细胞与正常12天胚胎的卵黄囊在电镜特征上的相似性表明，肿瘤起源于卵黄囊细胞。对从其中一个卵黄囊瘤建立的体外细胞系进行染色体分析发现，肿瘤由具有XX和XY性染色体组成的克隆构成。1p +标记被确定为一种一致的异常，它似乎在中国仓鼠卵黄囊瘤的发生中起重要作用。
