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SARS-CoV-2 攻击薄弱点 - 弗里德里希共济失调儿童患者的 COVID-19 病程。

SARS-CoV-2 attacks the weakest point - COVID-19 course in a pediatric patient with Friedreich's ataxia.

机构信息

Poznan University of Medical Sciences, Department of Infectious Diseases and Child Neurology, Poznań, Poland.

Poznan University of Medical Sciences, Department of Pediatric Cardiology, Poznań, Poland.

出版信息

Int J Infect Dis. 2022 Apr;117:284-286. doi: 10.1016/j.ijid.2022.02.021. Epub 2022 Feb 13.

Abstract

COVID-19 pandemic is the biggest epidemiologic problem of the 21st century. A severe course of SARS-CoV-2 infection in children is rare. Sometimes, especially in patients with chronic disease, COVID-19 may be insidious and life-threatening. This article presents the course of COVID-19 in a 17-year-old boy with Friedreich's ataxia-induced hypertrophic cardiomyopathy. Although, the main symptoms of COVID-19 (i.e., fever, cough) were moderate at the beginning of the illness, the patient's condition deteriorated rapidly due to cardiac problems, atrial fibrillation, and heart failure. The patient required antiarrhythmic treatment and pharmacological and electrical cardioversion. Moreover, because of pneumonia requiring supplemental oxygen, remdesivir and convalescent plasma therapy was given to the patient., The administration of the antiviral treatment was crucial to the patient's recovery.

摘要

COVID-19 大流行是 21 世纪最大的流行病学问题。儿童中严重的 SARS-CoV-2 感染病程罕见。有时,特别是在患有慢性病的患者中,COVID-19 可能是隐匿且危及生命的。本文介绍了一例伴有弗里德里希共济失调引起的肥厚型心肌病的 17 岁男孩的 COVID-19 病程。尽管 COVID-19 的主要症状(即发热、咳嗽)在疾病初期为中等程度,但由于心脏问题、心房颤动和心力衰竭,患者的病情迅速恶化。该患者需要抗心律失常治疗以及药物和电复律。此外,由于肺炎需要补充氧气,该患者还接受了瑞德西韦和恢复期血浆治疗。抗病毒治疗的应用对患者的康复至关重要。

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Worldwide Survey of COVID-19-Associated Arrhythmias.COVID-19 相关心律失常的全球调查。
Circ Arrhythm Electrophysiol. 2021 Mar;14(3):e009458. doi: 10.1161/CIRCEP.120.009458. Epub 2021 Feb 7.
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Meta-Analysis of Atrial Fibrillation in Patients With COVID-19.新型冠状病毒肺炎患者心房颤动的Meta分析
Am J Cardiol. 2021 Apr 1;144:152-156. doi: 10.1016/j.amjcard.2021.01.010. Epub 2021 Jan 27.
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COVID-19 in Pediatric Patients: A Focus on CHD Patients.儿科患者中的新型冠状病毒肺炎:聚焦先天性心脏病患者
Front Cardiovasc Med. 2020 Nov 27;7:612460. doi: 10.3389/fcvm.2020.612460. eCollection 2020.
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Predictors of COVID-19 severity: A literature review.预测 COVID-19 严重程度的因素:文献综述。
Rev Med Virol. 2021 Jan;31(1):1-10. doi: 10.1002/rmv.2146. Epub 2020 Jul 30.

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