Kim Jong-Min, Woo Chang Gok, Kim Sa Hun, Jeong Eui-Suk, Kim Kil-Soo, Kang Byeong-Cheol
Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, 110-799, Korea.
Department of Pathology, Chungbuk National University College of Medicine, Cheongju, 361-763, Korea.
Lab Anim Res. 2022 Feb 16;38(1):4. doi: 10.1186/s42826-022-00114-7.
Pulmonary venous aneurysm (PVA) is a rare condition characterized by aneurysmal dilatation of the pulmonary vein in humans. The diagnosis is incidental usually as there are no clinical symptoms. This case report describes a histological diagnosis of PVA in a New Zealand White rabbit.
A 1.5-kg male New Zealand White rabbit was acclimatized in an animal room for 5 weeks until the experiment began. However, the rabbit was found dead, with signs of nasal hemorrhage. Necropsy revealed tracheal and pulmonary hemorrhage, and the epistaxis had a pulmonary origin. PCR and ELISA to detect antigens and antibodies pertaining to the rabbit hemorrhagic disease virus showed negative results. Multiple ballooning lesions (50-200 μm size) in the pulmonary veins were observed on histological examination, and PVA was diagnosed. Death was attributed to a spontaneous rupture of the PVA and massive hemorrhage into the lung parenchyma that extended into the trachea and nasal passages.
To the author's best knowledge, this is the first report of a PVA in a rabbit.
肺静脉瘤（PVA）是一种罕见的疾病，其特征是人类肺静脉出现瘤样扩张。通常因无临床症状，诊断多为偶然发现。本病例报告描述了一只新西兰白兔的PVA组织学诊断情况。
一只1.5千克的雄性新西兰白兔在动物房适应环境5周后开始实验。然而，该兔被发现死亡，有鼻出血迹象。尸检显示气管和肺部出血，鼻出血源于肺部。检测兔出血性疾病病毒相关抗原和抗体的聚合酶链反应（PCR）和酶联免疫吸附测定（ELISA）结果均为阴性。组织学检查发现肺静脉有多个气球样病变（大小为50 - 200微米），诊断为PVA。死亡原因是PVA自发破裂，大量出血进入肺实质并蔓延至气管和鼻腔。
据作者所知，这是关于兔PVA的首例报告。
