从全基因组表达谱中筛选出的结核分枝杆菌H37Rv中上调的毒力基因。
Up regulated virulence genes in M. tuberculosis H37Rv gleaned from genome wide expression profiles.
作者信息
Kumari Rohini, Katara Pramod
机构信息
Computational Omics Lab, Centre of Bioinformatics, University of Allahabad, Prayagraj, Uttar Pradesh - 211002 India.
出版信息
Bioinformation. 2021 Jun 30;17(6):608-615. doi: 10.6026/97320630017608. eCollection 2021.
Abstract
Identification of up regulated virulence genes in M. tuberculosis H37Rv using genome wide expression profiles is of interest in drug discovery for the disease. Hence, we report 17 up-regulated PPIN (Protein-Protein Interaction Network) enriched potential virulence linked genes using expression data available at the Gene Expression Omnibus (GEO) database for further consideration.
摘要
利用全基因组表达谱鉴定结核分枝杆菌H37Rv中上调的毒力基因，对于该疾病的药物发现具有重要意义。因此，我们利用基因表达综合数据库（GEO）中可用的表达数据，报告了17个上调的富含蛋白质-蛋白质相互作用网络（PPIN）且与潜在毒力相关的基因，以供进一步研究。
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