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自闭症谱系障碍中前额叶-后叶信息处理模式的改变

Alterations of Prefrontal-Posterior Information Processing Patterns in Autism Spectrum Disorders.

作者信息

Zhao Hai-Chen, Lv Rui, Zhang Guang-Yu, He Le-Min, Cai Xiao-Tao, Sun Qiang, Yan Chun-Yan, Bao Xiang-Yuan, Lv Xin-Yue, Fu Bin

机构信息

Department of Radiology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, China.

出版信息

Front Neurosci. 2022 Jan 31;15:768219. doi: 10.3389/fnins.2021.768219. eCollection 2021.

DOI:10.3389/fnins.2021.768219
PMID:35173572
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8841879/
Abstract

Autism spectrum disorder (ASD) is a heterogeneous disorder characterized by different levels of repetitive and stereotypic behavior as well as deficits in social interaction and communication. In this current study, we explored the changes in cerebral neural activities in ASD. The purpose of this study is to investigate whether there exists a dysfunction of interactive information processing between the prefrontal cortex and posterior brain regions in ASD. We investigated the atypical connectivity and information flow between the prefrontal cortex and posterior brain regions in ASD utilizing the entropy connectivity (a kind of directional connectivity) method. Eighty-nine patients with ASD and 94 typical developing (TD) teenagers participated in this study. Two-sample t-tests revealed weakened interactive entropy connectivity between the prefrontal cortex and posterior brain regions. This result indicates that there exists interactive prefrontal-posterior underconnectivity in ASD, and this disorder might lead to less prior knowledge being used and updated. Our proposals highlighted that aforementioned atypical change might accelerate the deoptimization of brain networks in ASD.

摘要

自闭症谱系障碍（ASD）是一种异质性疾病，其特征是存在不同程度的重复刻板行为以及社交互动和沟通缺陷。在本研究中，我们探索了ASD患者大脑神经活动的变化。本研究的目的是调查ASD患者前额叶皮层与后脑区域之间是否存在交互信息处理功能障碍。我们利用熵连接性（一种方向性连接性）方法研究了ASD患者前额叶皮层与后脑区域之间的非典型连接性和信息流。89名ASD患者和94名发育正常（TD）的青少年参与了本研究。双样本t检验显示前额叶皮层与后脑区域之间的交互熵连接性减弱。这一结果表明ASD患者存在前额叶-后脑交互连接不足，这种疾病可能导致较少使用和更新先验知识。我们的研究结果强调，上述非典型变化可能会加速ASD患者脑网络的去优化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa60/8841879/29fc941b882a/fnins-15-768219-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa60/8841879/bd4cf3573aef/fnins-15-768219-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa60/8841879/3bf8b0f43bab/fnins-15-768219-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa60/8841879/dcd0d40ccf2c/fnins-15-768219-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa60/8841879/5f8d69032b72/fnins-15-768219-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa60/8841879/1e7fd27ebfdf/fnins-15-768219-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa60/8841879/29fc941b882a/fnins-15-768219-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa60/8841879/bd4cf3573aef/fnins-15-768219-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa60/8841879/3bf8b0f43bab/fnins-15-768219-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa60/8841879/dcd0d40ccf2c/fnins-15-768219-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa60/8841879/5f8d69032b72/fnins-15-768219-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa60/8841879/1e7fd27ebfdf/fnins-15-768219-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa60/8841879/29fc941b882a/fnins-15-768219-g0006.jpg

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