Malik Sairish, Sundarrajan Subramanian, Hussain Tanveer, Nazir Ahsan, Ramakrishna Seeram
Electrospun Materials & Polymeric Membranes Research Group (EMPMRG), National Textile University, Faisalabad, Pakistan.
Department of Mechanical Engineering, National University of Singapore, Singapore, Singapore.
Cells Tissues Organs. 2022;211(4):492-505. doi: 10.1159/000511866. Epub 2021 Feb 17.
Research on synthesis, characterization, and understanding of novel properties of nanomaterials has led researchers to exploit their potential applications. When compared to other nanotechnologies described in the literature, electrospinning has received significant interest due to its ability to synthesize novel nanostructures (such as nanofibers, nanorods, nanotubes, etc.) with distinctive properties such as high surface-to-volume ratio, porosity, various morphologies such as fibers, tubes, ribbons, mesoporous and coated structures, and so on. Various materials such as polymers, ceramics, and composites have been fabricated using the electrospinning technique. Among them, polymers, especially block copolymers, are one of the useful and niche systems studied recently owing to their unique and fascinating properties in both solution and solid state due to thermodynamic incompatibility of the blocks, that results in microphase separation. Morphology and mechanical properties of electrospun block copolymers are intensely influenced by quantity and length of soft and hard segments. They are one of the best studied systems to fit numerous applications due to a broad variety of properties they display upon varying the composition ratio and molecular weight of blocks. In this review, the synthesis, fundamentals, electrospinning, and tissue engineering application of block copolymers are highlighted.
对纳米材料的合成、表征及其新特性的研究促使研究人员开发其潜在应用。与文献中描述的其他纳米技术相比，静电纺丝因其能够合成具有独特特性（如高比表面积、孔隙率、各种形态，如纤维、纳米棒、纳米管等）的新型纳米结构而备受关注。利用静电纺丝技术已经制备了各种材料，如聚合物、陶瓷和复合材料。其中，聚合物，尤其是嵌段共聚物，是近年来研究的有用且独特的体系之一，由于其嵌段的热力学不相容性，在溶液和固态中都具有独特而迷人的性质，导致微相分离。静电纺丝嵌段共聚物的形态和力学性能受到软段和硬段的数量和长度的强烈影响。由于它们在改变嵌段的组成比和分子量时表现出广泛的性质，它们是最适合众多应用的研究体系之一。在这篇综述中，重点介绍了嵌段共聚物的合成、基本原理、静电纺丝及其在组织工程中的应用。
