Xu Jing, Xu Hao-Ming, Yang Mei-Feng, Liang Yu-Jie, Peng Quan-Zhou, Zhang Yuan, Tian Cheng-Mei, Wang Li-Sheng, Yao Jun, Nie Yu-Qiang, Li De-Feng
Department of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Department of Hematology, Yantian District People's Hospital, Shenzhen, China.
Front Pharmacol. 2022 Jan 31;13:813659. doi: 10.3389/fphar.2022.813659. eCollection 2022.
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the colonic mucosa. Environmental factors, genetics, intestinal microbiota, and the immune system are all involved in the pathophysiology of IBD. Lately, accumulating evidence has shown that abnormal epigenetic changes in DNA methylation, histone markers, and non-coding RNA expression greatly contribute to the development of the entire disease. Epigenetics regulates many functions, such as maintaining the homeostasis of the intestinal epithelium and regulating the immune system of the immune cells. In the present study, we systematically summarized the latest advances in epigenetic modification of IBD and how epigenetics reveals new mechanisms of IBD. Our present review provided new insights into the pathophysiology of IBD. Moreover, exploring the patterns of DNA methylation and histone modification through epigenetics can not only be used as biomarkers of IBD but also as a new target for therapeutic intervention in IBD patients.
炎症性肠病（IBD）是结肠黏膜的一种慢性炎症性疾病。环境因素、遗传学、肠道微生物群和免疫系统均参与IBD的病理生理过程。最近，越来越多的证据表明，DNA甲基化、组蛋白标记和非编码RNA表达方面的异常表观遗传变化在整个疾病的发展中起很大作用。表观遗传学调节许多功能，如维持肠道上皮的稳态和调节免疫细胞的免疫系统。在本研究中，我们系统总结了IBD表观遗传修饰的最新进展以及表观遗传学如何揭示IBD的新机制。我们目前的综述为IBD的病理生理学提供了新的见解。此外，通过表观遗传学探索DNA甲基化和组蛋白修饰模式不仅可以用作IBD的生物标志物，还可以作为IBD患者治疗干预的新靶点。
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