Anatol Joaquín, Vignali Emanuele, Gasparotti Emanuele, Castro-Ruiz Francisco, Rubio Manuel, Barrios-Collado César, Sierra-Pallares Jose, Celi Simona
Departamento de Ingeniería Energética y Fluidomecánica, Universidad de Valladolid, Paseo del Cauce 59, 47011, Valladolid, Spain.
BioCardioLab, Fondazione Toscana G. Monasterio, 54100, Massa, Italy.
Ann Biomed Eng. 2025 Apr;53(4):966-979. doi: 10.1007/s10439-024-03672-0. Epub 2025 Jan 26.
Extracorporeal Membrane Oxygenation (ECMO) is a modality of extracorporeal life support which allows temporary support in cases of cardiopulmonary failure and cardiogenic shock. This study presents a valveless pump that works by the Liebau effect as a possible pumping system in ECMO circuits, replacing the current roller and centrifugal pumps. For this purpose, a mock circulatory loop emulating the haemodynamic of the right part of the heart has been constructed. A veno-venous ECMO circuit with the integrated Liebau pump has been incorporated to analyse its performance. The Liebau pump in the ECMO circuit showed a flow assistance in the range of paediatric ECMO and low blood flow range for adults. In addition, experimental tests conducted demonstrated the advantage of the Liebau pump over currently used pumps as the ability to generate a pulsatile flow, which has many advantages in biomedical applications.
体外膜肺氧合（ECMO）是一种体外生命支持方式，可在心肺衰竭和心源性休克的情况下提供临时支持。本研究展示了一种基于利鲍效应工作的无阀泵，作为ECMO回路中可能的泵血系统，以取代当前的滚压泵和离心泵。为此，构建了一个模拟右心血流动力学的模拟循环回路。已将集成利鲍泵的静脉-静脉ECMO回路纳入以分析其性能。ECMO回路中的利鲍泵在儿科ECMO流量范围和成人低血流量范围内显示出流量辅助作用。此外，进行的实验测试证明了利鲍泵相对于当前使用的泵的优势，即能够产生脉动流，这在生物医学应用中有许多优点。
