Shigemoto Yoko, Matsuda Hiroshi, Kimura Yukio, Chiba Emiko, Ohnishi Masahiro, Nakaya Moto, Maikusa Norihide, Ogawa Masayo, Mukai Yohei, Takahashi Yuji, Sako Kazuya, Toyama Hiroshi, Inui Yoshitaka, Taki Yasuyuki, Nagayama Hiroshi, Ono Kenjiro, Kono Atsushi, Sekiguchi Kenji, Hirano Shigeki, Sato Noriko
Department of Radiology, National Center Hospital of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo, 187-8551, Japan.
Drug Discovery and Cyclotron Research Center, Southern TOHOKU Research Institute for Neuroscience, Koriyama, 963-8052, Japan.
Ann Nucl Med. 2022 May;36(5):460-467. doi: 10.1007/s12149-022-01725-9. Epub 2022 Feb 16.
Although previous studies have investigated age and gender effects on striatal subregional dopamine transporter (DaT) binding, these studies were mostly based on a conventional regions of interest-based analysis. Here, we investigated age and gender effects on striatal DaT binding at the voxel level, using a multicenter database of [()I] N-omega-fluoropropyl-2beta-carbomethoxy-3beta-{4-iodophenyl}nortropane ([()I] FP-CIT)-single photon emission computed tomography (SPECT) scans in 256 healthy Japanese adults.
We used the Southampton method to calculate the specific binding ratios (SBRs) of each subject's striatum and then converted the [I] FP-CIT SPECT images to quantitative SBRs images. To investigate the effects of age and gender effects on striatal DaT binding, we performed a voxel-based analysis using statistical parametric mapping. Gender differences were also compared between young to middle-aged subjects and elderly subjects (age threshold: 60 years).
When all subjects were explored as a group, DaT binding throughout the striatum decreased with advancing age. Among all subjects, the females showed higher DaT binding in the bilateral caudate compared to the males. In the young to middle-aged subjects, the females showed higher DaT binding throughout the striatum (with a slight caudate predominance) versus the males. In the elderly, there were no gender differences in striatal DaT binding.
Our findings of striatal subregional age- and gender-related differences may provide useful information to construct a more detailed DaT database in healthy Japanese subjects.
尽管先前的研究已经调查了年龄和性别对纹状体亚区域多巴胺转运体（DaT）结合的影响，但这些研究大多基于传统的基于感兴趣区域的分析。在此，我们使用一个包含256名健康日本成年人的[（）I]N-ω-氟丙基-2β-甲氧基羰基-3β-{4-碘苯基}去甲托烷（[（）I]FP-CIT）-单光子发射计算机断层扫描（SPECT）扫描的多中心数据库，在体素水平上研究年龄和性别对纹状体DaT结合的影响。
我们使用南安普敦方法计算每个受试者纹状体的特异性结合率（SBR），然后将[I]FP-CIT SPECT图像转换为定量SBR图像。为了研究年龄和性别对纹状体DaT结合的影响，我们使用统计参数映射进行了基于体素的分析。还比较了青年至中年受试者与老年受试者（年龄阈值：60岁）之间的性别差异。
当将所有受试者作为一个整体进行研究时，整个纹状体的DaT结合随年龄增长而降低。在所有受试者中，女性双侧尾状核的DaT结合高于男性。在青年至中年受试者中，女性整个纹状体的DaT结合（以尾状核略有优势）高于男性。在老年人中，纹状体DaT结合没有性别差异。
我们关于纹状体亚区域年龄和性别相关差异的研究结果可能为构建更详细的健康日本受试者DaT数据库提供有用信息。
