Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, 187-8551, Japan.
Department of Neurology, National Center Hospital of Neurology and Psychiatry, Kodaira, Tokyo, Japan.
Eur J Nucl Med Mol Imaging. 2018 Jul;45(8):1405-1416. doi: 10.1007/s00259-018-3976-5. Epub 2018 Feb 24.
The aim of this multicenter trial was to generate a [I]FP-CIT SPECT database of healthy controls from the common SPECT systems available in Japan.
This study included 510 sets of SPECT data from 256 healthy controls (116 men and 140 women; age range, 30-83 years) acquired from eight different centers. Images were reconstructed without attenuation or scatter correction (NOACNOSC), with only attenuation correction using the Chang method (ChangACNOSC) or X-ray CT (CTACNOSC), and with both scatter and attenuation correction using the Chang method (ChangACSC) or X-ray CT (CTACSC). These SPECT images were analyzed using the Southampton method. The outcome measure was the specific binding ratio (SBR) in the striatum. These striatal SBRs were calibrated from prior experiments using a striatal phantom.
The original SBRs gradually decreased in the order of ChangACSC, CTACSC, ChangACNOSC, CTACNOSC, and NOACNOSC. The SBRs for NOACNOSC were 46% lower than those for ChangACSC. In contrast, the calibrated SBRs were almost equal under no scatter correction (NOSC) conditions. A significant effect of age was found, with an SBR decline rate of 6.3% per decade. In the 30-39 age group, SBRs were 12.2% higher in women than in men, but this increase declined with age and was absent in the 70-79 age group.
This study provided a large-scale quantitative database of [I]FP-CIT SPECT scans from different scanners in healthy controls across a wide age range and with balanced sex representation. The phantom calibration effectively harmonizes SPECT data from different SPECT systems under NOSC conditions. The data collected in this study may serve as a reference database.
本多中心试验旨在从日本常用的 SPECT 系统中生成[I]FP-CIT SPECT 健康对照者数据库。
本研究纳入了来自 8 个不同中心的 256 名健康对照者（116 名男性，140 名女性；年龄 30-83 岁）的 510 套 SPECT 数据。图像在不进行衰减或散射校正（NOACNOSC）、仅使用 Chang 法（ChangACNOSC）或 X 射线 CT（CTACNOSC）进行衰减校正、以及仅使用 Chang 法（ChangACSC）或 X 射线 CT（CTACSC）进行散射和衰减校正的情况下进行重建。这些 SPECT 图像使用南安普顿方法进行分析。测量指标为纹状体的特异性结合比（SBR）。这些纹状体 SBR 使用纹状体体模在先前的实验中进行校准。
原始 SBR 逐渐按照 ChangACSC、CTACSC、ChangACNOSC、CTACNOSC 和 NOACNOSC 的顺序降低。与 ChangACSC 相比，NOACNOSC 的 SBR 低 46%。相比之下，在没有散射校正（NOSC）的情况下，校准后的 SBR 几乎相等。年龄存在显著影响，SBR 下降率为每 10 年 6.3%。在 30-39 岁年龄组中，女性的 SBR 比男性高 12.2%，但这种增加随着年龄的增长而下降，在 70-79 岁年龄组中则不存在。
本研究提供了一个来自不同扫描仪的[I]FP-CIT SPECT 扫描的大型健康对照者定量数据库，涵盖了广泛的年龄范围和均衡的性别代表性。体模校准在 NOSC 条件下有效地协调了来自不同 SPECT 系统的 SPECT 数据。本研究中收集的数据可作为参考数据库。
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