Yamamoto Hideo, Arimura Shinichi, Nakanishi Atsushi, Shimo Yasushi, Motoi Yumiko, Ishiguro Koichi, Murakami Koji, Hattori Nobutaka, Aoki Shigeki
Department of Radiology, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Department of Neurology, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Ann Nucl Med. 2017 Jun;31(5):407-412. doi: 10.1007/s12149-017-1168-1. Epub 2017 Apr 5.
Dopamine transporter (DAT) imaging with [I]FP-CIT (DaTSCAN) is a widely used diagnostic tool for Parkinsonism and dementia. Since it was approved by the Japanese Ministry of Health, Labor, and Welfare in 2013, there have been no articles focusing on a Japanese normal population. The aim of this study was to examine the effect of aging and gender on DAT availability in Japanese people.
SPECT imaging of 30 healthy Japanese controls (17 males, 13 females; range 50-86 years, mean 70 years) was performed. SPECT images were reconstructed using a three-dimensional order subset expectation maximization (OSEM) algorithm with correction of the point spread function and scatter correction, without attenuation correction. The specific binding ratio (SBR) was calculated by DATview software. Statistical analyses were performed using linear regression analysis, analysis of variance, and multiple comparison analysis.
A strong correlation between the SBR and age was observed. The correlation coefficient in males and females were -0.566 and -0.502, respectively. The analysis of variance revealed that aging led to a decline of the SBR, and a significant difference (p = 0.005) was observed among generations. Gender also affected the SBR, and there was a significant difference between males and females (p = 0.036). The SBR in females was higher than in males. Consequently, the multiple comparison revealed a significant difference between 50s and 70s (p = 0.015) and 50s and 80s (p = 0.006).
This is the first [I]FP-CIT SPECT study on subjects with normal dopamine function in Asian countries. This study provides a database of [I]FP-CIT SPECT in Japanese healthy controls. Higher DAT availability was found in women than in men. An average age-related decline in DAT availability of 8.9% was found in both genders. The data collected in this study would be helpful for Japanese physicians to make a differential diagnosis in Parkinsonian syndrome. The registration identification number for this study is UMIN000018045.
使用[I]FP-CIT（DaTSCAN）进行多巴胺转运体（DAT）成像，是帕金森病和痴呆症广泛使用的诊断工具。自2013年被日本厚生劳动省批准以来，尚未有聚焦日本正常人群的文章。本研究的目的是研究年龄和性别对日本人DAT可用性的影响。
对30名健康日本对照者（17名男性，13名女性；年龄范围50 - 86岁，平均70岁）进行单光子发射计算机断层扫描（SPECT）成像。SPECT图像使用三维有序子集期望最大化（OSEM）算法重建，校正点扩散函数并进行散射校正，但不进行衰减校正。通过DATview软件计算特异性结合率（SBR）。使用线性回归分析、方差分析和多重比较分析进行统计分析。
观察到SBR与年龄之间存在强相关性。男性和女性的相关系数分别为 -0.566和 -0.502。方差分析显示，衰老导致SBR下降，各代之间存在显著差异（p = 0.005）。性别也影响SBR，男性和女性之间存在显著差异（p = 0.036）。女性的SBR高于男性。因此，多重比较显示50多岁与70多岁之间（p = 0.015）以及50多岁与80多岁之间（p = 0.006）存在显著差异。
这是亚洲国家首次对多巴胺功能正常的受试者进行的[I]FP-CIT SPECT研究。本研究提供了日本健康对照者的[I]FP-CIT SPECT数据库。发现女性的DAT可用性高于男性。在两性中均发现DAT可用性平均随年龄下降8.9%。本研究收集的数据将有助于日本医生对帕金森综合征进行鉴别诊断。本研究的注册识别号为UMIN000018045。
