Role of Imbalance of Lipid Peroxidation and Articular Cartilage Remodeling in the Pathogenesis of Early Primary and Post-Traumatic Gonarthrosis in Rats.

We studied serum indicators of LPO and antioxidant system mechanisms in nonlinear male white rats at the early stages of simulated primary knee osteoarthrosis (n=60) and posttraumatic knee osteoarthrosis (n=60) as well as in intact animals (n=20). An imbalance in the peroxidation-antioxidant system with accumulation of lipoperoxides and malondialdehyde along with a decrease in catalase and superoxide dismutase activities was revealed. Early stages of osteoarthrosis were characterized by increased production of primary and intermediate LPO products and exhaustion of the antioxidant system enzymes.