Bone Tissue Metabolism in Dynamics of Experimental Knee Osteoarthrosis Induced by Dexamethasone and Talcum.

We studied remodeling of the bone tissue in the dynamics of experimental dexamethasoneand talcum-induced knee osteoarthrosis. Disturbed osteoclastogenesis accompanied by a decrease in the production of fibroblast growth factor-23 and elevation of serum osteoprotegerin and osteocalcin were observed at the early stages of the disease. During progression of degenerative and dystrophic processes in the joint tissues, an increase in sclerostin concentrations, a decrease in osteocalcin content, and changes in the force and direction of correlations between osteoblast processes and osteoclastogenesis as well as hierarchic distribution of the dominating mechanism of subchondral remodeling were revealed.