Radha T G, Viswanathan R
Respiration. 1978;36(2):104-11. doi: 10.1159/000193933.
Allergic bronchopulmonary aspergillosis (ABPA) is not a common condition, even though asthma due to sensitization to Aspergillus antigen is very common in many countries because of the ubiquitous distribution of the fungus itself. During the course of 14 years, the Mycology Department of the V. P. Chest Institute, Delhi, has confirmed the diagnosis of ABPA in 46 patients. The present study is based on the follow-up of 17 patients for understanding the evolution of the disease. All of them had Aspergillus fumigatus (AF) in the sputum with positive type I and type III skin reaction to AF antigen. 7 patients were treated for 10 days with oral administration of Hamycin, an antibiotic isolated from one of the streptomycete species. Immediate results were very good, with marked alleviation of subjective symptoms and absence of fungi in the sputum. The drug deserves further trial.
变应性支气管肺曲霉病（ABPA）并不常见，尽管在许多国家，由于曲霉菌本身分布广泛，因对曲霉抗原致敏而导致的哮喘很常见。在14年的时间里，德里V.P.胸科研究所真菌学部门确诊了46例ABPA患者。本研究基于对17例患者的随访，以了解该疾病的发展过程。所有患者痰中均有烟曲霉（AF），且对AF抗原的I型和III型皮肤反应呈阳性。7例患者口服从链霉菌属的一个菌种中分离出的抗生素哈霉素治疗10天。即刻效果非常好，主观症状明显缓解，痰中无真菌。该药物值得进一步试验。
