From the Department of Nuclear Medicine, Hanyang University Medical Center.
Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
Clin Nucl Med. 2022 May 1;47(5):e397-e398. doi: 10.1097/RLU.0000000000004094.
Of the various adverse reactions to COVID-19 vaccines, fever is a common systemic symptom that often resolves spontaneously without treatment. However, rare vaccine-induced conditions that present with fever and systemic inflammation have been reported. In this case, a 65-year-old man with BNT162b2 mRNA COVID-19 vaccination underwent 18F-FDG PET/CT to evaluate prolonged fever and elevated serum C-reactive protein. PET/CT showed hypermetabolic infiltration in the pericardium and peritoneum suggesting immune-mediated pericarditis and peritonitis. After administration of high-dose corticosteroids, the patient's symptom resolved. This case suggests that multisystem inflammatory syndrome and polyserositis can be induced by the COVID-19 vaccine.
在各种与 COVID-19 疫苗相关的不良反应中，发热是一种常见的全身症状，通常无需治疗即可自行缓解。然而，也有罕见的疫苗诱导的发热和全身炎症性疾病的报道。在本病例中，一名接受 BNT162b2 mRNA COVID-19 疫苗接种的 65 岁男性因持续性发热和血清 C 反应蛋白升高而行 18F-FDG PET/CT 检查。PET/CT 显示心包和腹膜呈高代谢浸润，提示免疫介导性心包炎和腹膜炎。给予大剂量皮质类固醇后，患者症状缓解。该病例提示 COVID-19 疫苗可引起多系统炎症综合征和多浆膜炎。
