Donaldson D, Evans O B, Harrison R W
Muscle Nerve. 1986 Mar-Apr;9(3):211-5. doi: 10.1002/mus.880090304.
Insulin binding was measured in rat muscle following denervation. There was a 40% reduction in the number of high-affinity insulin receptors, with no change in the insulin binding Kd. Selected muscles showed a 40%-60% reduction in weight during this period. The down-regulation in the number of insulin receptors may contribute to the mechanism of muscle atrophy following denervation.
在去神经支配后的大鼠肌肉中测量胰岛素结合情况。高亲和力胰岛素受体数量减少了40%，而胰岛素结合解离常数（Kd）没有变化。在此期间，选定的肌肉重量减少了40%-60%。胰岛素受体数量的下调可能有助于解释去神经支配后肌肉萎缩的机制。
