Bezdrobnyĭ Iu V, Komissarenko V P, Evdokimova N Iu, Opanasiuk N D, Efimov A S
Fiziol Zh SSSR Im I M Sechenova. 1985 Feb;71(2):248-54.
Section of the hepatic nervous plexus did not affect insulin receptor parameters in hepatic or adipose tissue plasma membranes. In control rats, the increase of the receptor insulin binding in fasting and its fall under experimental hyperinsulinemia were found both in hepatic and adipose tissue membranes, while in the rats with lesioned hepatic innervation these changes only occurred in adipose tissue membranes. No insulin receptor response to fasting or hyperinsulinemia in the rat liver with lesioned innervation occurred. The vegetative nervous system seems to affect the insulin receptors in the insulin target tissues. The nervous regulation of the receptors in addition to the humoral one, increases the effectiveness of the insulin metabolic control in its target cells.
肝神经丛切断术并不影响肝组织或脂肪组织质膜中的胰岛素受体参数。在对照大鼠中，无论是肝组织膜还是脂肪组织膜，均发现空腹时受体胰岛素结合增加，而在实验性高胰岛素血症时其降低；而在肝神经支配受损的大鼠中，这些变化仅发生在脂肪组织膜中。肝神经支配受损的大鼠肝脏对空腹或高胰岛素血症无胰岛素受体反应。自主神经系统似乎会影响胰岛素靶组织中的胰岛素受体。除体液调节外，受体的神经调节增加了胰岛素在其靶细胞中代谢控制的有效性。
