Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Integral University, Lucknow 226026, India.
Mini Rev Med Chem. 2022;22(14):1895-1935. doi: 10.2174/1389557522666220217101805.
The therapeutic potential of the majority of the marketed drugs is due to the presence of a heterocyclic nucleus, which constitutes a huge role in the field of medicinal chemistry. These heterocyclic scaffolds could act as a template in order to design potential therapeutic agents against several diseases. Benzothiazole scaffold is one of the influential heteroaromatic rings in the field of medicinal chemistry owing to its extensive pharmacological features. Herein, we have focused on the synthesis of benzothiazole-based medicinal molecules, which possess antimicrobial and anti-inflammatory activities. This review covers a systematic description of synthetic routes for biologically relevant benzothiazole derivatives in the last five years. The main aim of this study is to show the diversification of benzothiazole-based molecules into their pharmacologically more active derivatives. This review's synthetic protocols include metal-free, metal-catalyzed, and metal precursor azo dyes strategies for the development of benzothiazole derived bioactive compounds. The discussion under the various headings covers synthetic schemes and biological activities of the most potent molecules in the form of minimum inhibitory concentration.
市场上大多数药物的治疗潜力是由于存在杂环核，这在药物化学领域中起着巨大的作用。这些杂环支架可以作为模板，设计针对多种疾病的潜在治疗药物。苯并噻唑支架是药物化学领域中具有影响力的杂芳环之一，因为它具有广泛的药理特征。本文重点介绍了具有抗菌和抗炎活性的基于苯并噻唑的药物分子的合成。本综述涵盖了过去五年中具有生物相关性的苯并噻唑衍生物的合成路线的系统描述。本研究的主要目的是展示苯并噻唑类分子向具有更高药理活性的衍生物的多样化。本综述的合成方案包括无金属、金属催化和金属前体偶氮染料策略，用于开发苯并噻唑衍生的生物活性化合物。在各个标题下的讨论涵盖了最有效的分子的合成方案和最小抑制浓度形式的生物活性。
