Çakmak Güzin, Kaplan Davut Sinan, Yıldırım Caner, Ulusal Hasan, Tarakçıoğlu Mehmet, Öztürk Zeynel Abidin
Gaziantep University, Faculty of Medicine, Department of Internal Medicine, Division of Geriatric Medicine, Gaziantep, Turkey.
Gaziantep University, Faculty of Medicine, Department of Physiology, Gaziantep, Turkey.
Caspian J Intern Med. 2022 Winter;13(1):16-22. doi: 10.22088/cjim.13.1.16.
It has been suggested that curcumin may be useful in diseases with cognitive dysfunction because it slows the progression and leads to the improvement of cognitive functions. In this study, the protective effects of curcumin on scopolamine-induced rat models of cognitive impairment were evaluated.
21 male Wistar Albino rats, 1 year old, 200±25 grams, were included in the study. They were divided into three groups (n: 7 in each group); the untreated control group, scopolamine group, and the group treated with curcumin and then exposed to scopolamine. Animals were evaluated for behavioral tasks with the Morris Water Maze test. Interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), total oxidative status (TOS), and total antioxidative status (TAS) were measured in hippocampal tissues. CRP levels were measured in serum specimens.
We found that the length to reach the platform was the highest in the scopolamine group, and the lowest in the curcumin group (p<0.001). Time to reach the platform was the longest in the scopolamine group, and the shortest in the curcumin group (P=0.002). The length to reach the platform was the highest in the scopolamine group, and the lowest in the control group in the probe test (p<0.001). IL-6 levels were higher in the scopolamine group than the curcumin group (P=0.017) and the control group (P=0.005).
We revealed that curcumin provides a protective effect on scopolamine-induced cognitive impairment mimicking Alzheimer's disease. The use of curcumin for the protection of cognition in individuals at risk of developing AD may be considered.
有人提出姜黄素可能对患有认知功能障碍的疾病有用，因为它能减缓疾病进展并改善认知功能。在本研究中，评估了姜黄素对东莨菪碱诱导的大鼠认知障碍模型的保护作用。
本研究纳入了21只1岁、体重200±25克的雄性Wistar白化大鼠。它们被分为三组（每组n = 7）；未处理的对照组、东莨菪碱组以及用姜黄素处理后再暴露于东莨菪碱的组。通过莫里斯水迷宫试验对动物进行行为任务评估。测量海马组织中的白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、总氧化状态（TOS）和总抗氧化状态（TAS）。在血清样本中测量CRP水平。
我们发现，到达平台的路径长度在东莨菪碱组中最长，在姜黄素组中最短（p<0.001）。到达平台的时间在东莨菪碱组中最长，在姜黄素组中最短（P = 0.002）。在探针试验中，到达平台的路径长度在东莨菪碱组中最长，在对照组中最短（p<0.001）。东莨菪碱组的IL-6水平高于姜黄素组（P = 0.017）和对照组（P = 0.005）。
我们发现姜黄素对东莨菪碱诱导的模拟阿尔茨海默病的认知障碍具有保护作用。可以考虑使用姜黄素来保护有患阿尔茨海默病风险个体的认知功能。
