3型心肾综合征的肾脏相关结局
Kidney-Related Outcome in Cardiorenal Syndrome Type 3.
作者信息
Drubel Kim, Marahrens Benedikt, Ritter Oliver, Patschan Daniel
机构信息
Klinik für Kardiologie und Nephrologie, University Hospital Brandenburg, Medical School of Brandenburg, Brandenburg, Hochstraße 29, 14770 Brandenburg, Germany.
出版信息
Int J Nephrol. 2022 Feb 7;2022:4895434. doi: 10.1155/2022/4895434. eCollection 2022.
METHODS
A single-center, retrospective and observational trial. All subjects with positive AKI alert, treated at the University Hospital Brandenburg between January and December 2019, were evaluated. Definition of CRS type 3 was according to predefined criteria. The three endpoint categories were in-hospital death, dialysis, and recovery of kidney function.
RESULTS
. A total number of 1,334 AKI alerts were screened. Finally, 95 subjects received the diagnosis CRS type 3. The survival rates were 47.1% (females) and 43.6% (males). 46.8% of affected females and 33.3% of the males required dialysis therapy. Complete recovery at the time of discharge occurred in 35.8%, and no recovery at all was found in 54.7%.
CONCLUSIONS
. All three predefined study endpoints, the mortality, the prevalence of dialysis, and the percentage of subjects without recovery of kidney function, were notably high. Therefore, AKI patients with imminent or established cardiac complications require the highest attention of nephrologists in charge.
方法
一项单中心回顾性观察性试验。对2019年1月至12月在勃兰登堡大学医院接受治疗的所有急性肾损伤（AKI）警报呈阳性的受试者进行评估。3型心肾综合征（CRS）的定义依据预定义标准。三个终点类别为院内死亡、透析和肾功能恢复。
结果
共筛查了1334次AKI警报。最终，95名受试者被诊断为3型CRS。生存率分别为47.1%（女性）和43.6%（男性）。46.8%的受影响女性和33.3%的男性需要透析治疗。出院时完全恢复的比例为35.8%，完全未恢复的比例为54.7%。
结论
所有三个预定义的研究终点，即死亡率、透析患病率以及肾功能未恢复受试者的百分比，均显著较高。因此，患有即将发生或已确诊心脏并发症的AKI患者需要负责的肾脏病学家给予高度关注。
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