Department of Anesthesiology and Pain Medicine, Wonkwang University School of Medicine, 895 Muwang-ro, Iksan 54538, Republic of Korea.
Department of Obstetrics and Gynecology, Wonkwang University School of Medicine, 895 Muwang-ro, Iksan 54538, Republic of Korea.
Biomed Res Int. 2022 Feb 8;2022:5305165. doi: 10.1155/2022/5305165. eCollection 2022.
Previous studies reported the impact of intrinsic and extrinsic factors on intraoperative hypothermia. However, no clinical study to date has considered the effects of both the phase of the menstrual cycle (an intrinsic factor) and the fresh gas flow rate (FGF) during anesthesia (an extrinsic factor) on the core body temperature and intraoperative hypothermia. This study is aimed at investigatig the effect of the menstrual cycle phase on intraoperative hypothermia when considering the FGF in patients who underwent laparoscopic gynecologic surgery. This study included 667 women aged 19-65 years with menstruation cycles and menopause. The patients were divided into the follicular, luteal, and menopause groups. The primary outcome was the correlations of hormonal status with intraoperative hypothermia. Secondary outcomes included the incidence of intraoperative hypothermia, time to onset of hypothermia, incidence of shivering after anesthesia, and frequency of antishivering drug use in the three groups and risk factors for hypothermia. Overall, the hypothermia incidence was the lowest and the time to onset of hypothermia was the longest in the luteal phase group. At a high FGF, the incidence of hypothermia in the luteal phase group was lower than that in the other two groups ( < 0.05). At a low FGF, the time to onset of hypothermia in the luteal phase group was longer than that in the other two groups ( < 0.05). The female hormonal status had weak positive correlations with hypothermia at low and high FGF rates. A high FGF in univariate and multivariate analyses, follicular phase and menopause in multivariate analysis, and estradiol and progesterone levels in univariate analysis were risk factors for hypothermia. When considering the FGF, the luteal phase is associated with better outcomes concerning intraoperative hypothermia.
先前的研究报告了内在和外在因素对术中低体温的影响。然而，迄今为止，没有临床研究同时考虑月经周期阶段（内在因素）和麻醉期间新鲜气体流量（外在因素）对核心体温和术中低体温的影响。本研究旨在调查在考虑接受腹腔镜妇科手术的患者的 FGF 时，月经周期阶段对术中低体温的影响。本研究纳入了 667 名年龄在 19-65 岁之间、有月经周期和绝经的女性。患者分为卵泡期、黄体期和绝经期组。主要结局是激素状态与术中低体温的相关性。次要结局包括三组患者术中低体温的发生率、低体温发生时间、麻醉后寒战的发生率以及抗寒战药物的使用频率，以及低体温的危险因素。总体而言，黄体期组的低体温发生率最低，低体温发生时间最长。在高 FGF 时，黄体期组的低体温发生率低于其他两组（<0.05）。在低 FGF 时，黄体期组的低体温发生时间长于其他两组（<0.05）。低和高 FGF 时，女性激素状态与低体温呈弱正相关。单因素和多因素分析中 FGF 较高、多因素分析中卵泡期和绝经、单因素分析中雌二醇和孕酮水平是低体温的危险因素。在考虑 FGF 时，黄体期与术中低体温的更好结果相关。
