Department of Anesthesiology and Pain Medicine, Wonkwang University School of Medicine, 895 Muwang-ro, Iksan 54538, Korea.
Department of Obstetrics & Gynecology, Wonkwang University School of Medicine, 895 Muwang-ro, Iksan 54538, Korea.
Medicina (Kaunas). 2021 Nov 16;57(11):1255. doi: 10.3390/medicina57111255.
Female reproductive hormones may affect core body temperature. This study aimed to investigate the effects of female reproductive hormones on inadvertent intraoperative hypothermia in patients who underwent laparoscopic gynecologic surgery under general anesthesia. This retrospective study included 660 menstruating and menopausal female patients aged 19-65 years. The patients were divided into two groups according to the occurrence of inadvertent intraoperative hypothermia: non-hypothermia group ( = 472) and hypothermia group ( = 188). After propensity score matching, 312 patients ( = 156 in each group) were analyzed to investigate the association between intraoperative hypothermia and female reproductive hormones. As potential predictors of inadvertent hypothermia, the levels of female reproductive hormones were analyzed using binary logistic regression. The association of estradiol (r = -0.218, = 0.000) and progesterone (r = -0.235, = 0.000) levels with inadvertent intraoperative hypothermia was significant but weakly negative before matching; however, it was significant and moderately negative after matching (r = -0.326, = 0.000 and r = -0.485, = 0.000, respectively). In a binary logistic analysis, the odds ratio for estradiol was 0.995 ( = 0.014, 0.993 < 95% confidence interval [CI] < 0.998) before matching and 0.993 ( = 0.000, 0.862 < 95% CI < 0.930) after matching, and that for progesterone was 0.895 ( = 0.000, 0.862 < 95% CI < 0.930) before matching and 0.833 ( = 0.014, 0.990 < 95% CI < 0.996) after matching. Estradiol and progesterone levels were associated with inadvertent intraoperative hypothermia. However, the odds ratio for female reproductive hormone levels was close to 1. Therefore, female reproductive hormones may not be a risk factor for hypothermia during gynecologic surgery under general anesthesia. However, a small sample size in this study limits the generalizability of the results.
女性生殖激素可能会影响核心体温。本研究旨在探讨女性生殖激素对全麻下腹腔镜妇科手术中患者意外术中低体温的影响。这项回顾性研究纳入了 660 例 19-65 岁的月经期和绝经后女性患者。根据术中意外低体温的发生情况，将患者分为非低体温组（n=472）和低体温组（n=188）。在进行倾向评分匹配后，对 312 例患者（每组 156 例）进行分析，以探讨术中低体温与女性生殖激素之间的关系。将女性生殖激素水平作为意外低体温的潜在预测因素，采用二项逻辑回归进行分析。在匹配前，雌二醇（r=-0.218，p=0.000）和孕酮（r=-0.235，p=0.000）水平与意外术中低体温之间的相关性显著，但呈弱负相关；然而，在匹配后，这种相关性显著且呈中度负相关（r=-0.326，p=0.000 和 r=-0.485，p=0.000）。在二项逻辑分析中，雌二醇的比值比在匹配前为 0.995（p=0.014，0.993<95%置信区间[CI]<0.998），在匹配后为 0.993（p=0.000，0.862<95%CI<0.930），孕酮的比值比在匹配前为 0.895（p=0.000，0.862<95%CI<0.930），在匹配后为 0.833（p=0.014，0.990<95%CI<0.996）。雌二醇和孕酮水平与意外术中低体温相关。然而，女性生殖激素水平的比值比接近 1。因此，女性生殖激素可能不是全麻下妇科手术中低体温的危险因素。然而，本研究的样本量较小，限制了结果的普遍性。
