A Retrospective Trial Exploring Erzhu Yiren Decoction in Gastric Ulcer with Spleen Deficiency and Dampness-Heat.

OBJECTIVE

To assess the efficacy of Erzhu Yiren Decoction in treating gastric ulcer of spleen deficiency and dampness-heat and its effect on serum NO, EGF, and PGE2 levels.

METHODS

A retrospective study was conducted among 64 patients with gastric ulcers of spleen deficiency and dampness heat admitted to our hospital from September 2019 to May 2020, and they were divided at a ratio of 1 : 1 into an observation group (rabeprazole sodium enteric-coated capsules plus Erzhu Yiren Decoction) and a control group (rabeprazole sodium enteric-coated capsules) based on different treatment methods. The clinical symptom scores, the effective rate of ulcer healing under gastroscopy, the quality of ulcer healing (QOUH), serum nitric oxide (NO), endothelial growth factor (EGF), and prostaglandin E2 (PGE2) levels were compared between the two groups.

RESULTS

The clinical symptom scores of the observation group after treatment were significantly lower than those of the control group ( < 0.001). The observation group obtained a remarkably higher efficacy of ulcer healing under gastroscopy than the control group ( = 0.039). The observation group outperformed the control group in terms of the number of patients with excellent and good QOUH ( = 0.003, 0.014), but no statistical difference in the number of patients with poor QOUH between the two groups was found ( > 0.05). Serum NO, EGF, and PGE2 levels of the observation group after treatment were significantly better than those of the control group ( < 0.001).

CONCLUSION

Erzhu Yiren Decoction can relieve the clinical symptoms of patients with gastric ulcers of spleen deficiency and dampness heat; improve the serum NO, EGF, and PGE2 levels; optimize the mucosal maturity; and enhance the overall efficacy, which merits clinical promotion.