Tidman Melanie M, White Dawn, White Timothy
College of Graduate Health Studies AT Still University Mesa, AZ 85206, USA.
Neurodegener Dis Manag. 2022 Apr;12(2):57-66. doi: 10.2217/nmt-2021-0033. Epub 2022 Feb 18.
To evaluate a low carbohydrate/healthy fat/ketogenic diet (LCHF/KD) on symptoms, depression, anxiety and biomarkers in adults with Parkinson's disease (PD). 16 adults ages 36-80 with PD participated in the intervention for 12 weeks. The study provided pre-post-study comparisons of biomarkers, weight, waist measurement, united Parkinson's Disease Rating Scale (UPDRS), Parkinson's Anxiety Scale (PAS) and Center for Epidemiologic Studies Depression Scale Revised-20 (CESD-R-20) Depression Scale. Although LCHF/KD improves blood glucose in diabetes and seizure control in epilepsy, research gaps exist in this dietary intervention in PD. Statistically, significant improvements occurred in several measurements, PAS scores and Part I of the UPDRS. The LCHF/KD shows positive trends with improvements in biomarkers and anxiety symptoms. Further research is needed to evaluate dietary interventions for PD.
评估低碳水化合物/健康脂肪/生酮饮食（LCHF/KD）对帕金森病（PD）成人患者症状、抑郁、焦虑及生物标志物的影响。16名年龄在36 - 80岁的PD成人患者参与了为期12周的干预。该研究提供了生物标志物、体重、腰围、统一帕金森病评定量表（UPDRS）、帕金森焦虑量表（PAS）以及流行病学研究中心抑郁量表修订版20（CESD-R-20）的研究前后对比。尽管LCHF/KD可改善糖尿病患者的血糖以及癫痫患者的癫痫控制，但在PD的这种饮食干预方面仍存在研究空白。在统计学上，多项测量指标、PAS评分及UPDRS第一部分有显著改善。LCHF/KD在生物标志物和焦虑症状改善方面呈现积极趋势。需要进一步研究来评估针对PD的饮食干预。
