Weber T H, Wegelius R, Borgström G H, Gahmberg C G, Andersson L C
Scand J Haematol. 1979 Jan;22(1):47-52. doi: 10.1111/j.1600-0609.1979.tb00399.x.
A case of pure monocytic, 'Schilling-Type' leukaemia in a 9-year-old boy is described. The leukaemic cells resembled monocytes and were abundantly present in blood and bone marrow. They were strongly alpha-naphthyl-acetate-esterase positive, contained fine PAS-positive granules and did not stain by Sudan B. They were negative for surface bound and intracytoplasmic IgG, but had a high density of membrane Fc-receptors and showed phagocytosis. The surface glycoprotein pattern resembled that of monocytes, but was clearly different from those of lymphocytic and myelocytic cells or those of acute lymphocytic leukaemia cells. The karyotype of bone marrow cells was 44,X, -15, -21, +mar,del(2)(p11), with the missing Y-chromosome located in the marker chromosome. Especially the surface glycoprotein and membrane receptor analyses aided in the accurate classification of the monocytic origin of the leukaemic cells.
本文描述了一名9岁男孩患纯单核细胞型“希林氏型”白血病的病例。白血病细胞类似单核细胞，大量存在于血液和骨髓中。它们对α-萘乙酸酯酶呈强阳性，含有细小的PAS阳性颗粒，苏丹黑B染色阴性。它们表面结合型和胞浆内IgG均为阴性，但具有高密度的膜Fc受体并表现出吞噬作用。其表面糖蛋白模式类似于单核细胞，但明显不同于淋巴细胞、髓细胞或急性淋巴细胞白血病细胞的表面糖蛋白模式。骨髓细胞的核型为44,X,-15,-21,+mar,del(2)(p11)，缺失的Y染色体位于标记染色体中。特别是表面糖蛋白和膜受体分析有助于准确分类白血病细胞的单核细胞起源。
