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毒扁豆碱:改善正常人的长期记忆过程。

Physostigmine: improvement of long-term memory processes in normal humans.

作者信息

Davis K L, Mohs R C, Tinklenberg J R, Pfefferbaum A, Hollister L E, Kopell B S

出版信息

Science. 1978 Jul 21;201(4352):272-4. doi: 10.1126/science.351807.

DOI:10.1126/science.351807
PMID:351807
Abstract

Nineteen normal male subjects received 1.0 milligram of physostigmine or 1.0 milligram of saline by a slow intravenous infusion on two nonconsecutive days. Physostigmine significantly enhanced storage of information into long-term memory. Retrieval of information from long-term memory was also improved. Short-term memory processes were not significantly altered by physostigmine.

摘要

19名正常男性受试者在两个不连续的日子里,通过缓慢静脉输注接受了1.0毫克毒扁豆碱或1.0毫克生理盐水。毒扁豆碱显著增强了信息向长期记忆的存储。从长期记忆中检索信息也得到了改善。毒扁豆碱对短期记忆过程没有显著影响。

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Physostigmine: improvement of long-term memory processes in normal humans.毒扁豆碱:改善正常人的长期记忆过程。
Science. 1978 Jul 21;201(4352):272-4. doi: 10.1126/science.351807.
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Physostigmine and recent memory: effects in young and aged nonhuman primates.毒扁豆碱与近期记忆:对幼年和老年非人灵长类动物的影响
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Physostigmine: effects on cognition and affect in normal subjects.毒扁豆碱:对正常受试者认知和情感的影响。
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Acute and chronic effects of oral physostigmine and lecithin in Alzheimer's disease.口服毒扁豆碱和卵磷脂对阿尔茨海默病的急性和慢性影响。
Prog Neuropsychopharmacol Biol Psychiatry. 1986;10(3-5):627-36. doi: 10.1016/0278-5846(86)90032-1.
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Effects of physostigmine on memory test performance in normal volunteers.毒扁豆碱对正常志愿者记忆测试表现的影响。
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Enhancement of memory processes in Alzheimer's disease with multiple-dose intravenous physostigmine.多剂量静脉注射毒扁豆碱增强阿尔茨海默病患者的记忆过程
Am J Psychiatry. 1982 Nov;139(11):1421-4. doi: 10.1176/ajp.139.11.1421.
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Physostigmine and arecoline: effects of intravenous infusions in Alzheimer presenile dementia.毒扁豆碱和槟榔碱:静脉输注对早老性阿尔茨海默病痴呆的影响。
Br J Psychiatry. 1981 Jan;138:46-50. doi: 10.1192/bjp.138.1.46.

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