Sitaram N, Weingartner H, Gillin J C
Science. 1978 Jul 21;201(4352):274-6. doi: 10.1126/science.351808.
Arecholine (4 milligrams), a cholinergic agonist, and choline (10 grams), a precursor of acetylcholine, significantly enhanced serial learning in normal human subjects. The subjects received methscopolamine prior to both arecholine and placebo injections. Conversely, scopolamine (0.5 milligram), a cholinergic antagonist, impaired learning and this impairment was reversed by arecholine and choline and the impairment after scopolamine were inversely proportional to the subject's performance on placebo; that is, "poor" performers were more vulnerable to both the enhancing effect of cholinergic agonist and precursor and the impairment after cholinergic antagonist than "good" performers.
胆碱能激动剂阿考氯铵（4毫克）和乙酰胆碱前体胆碱（10克）显著增强了正常人类受试者的系列学习能力。受试者在注射阿考氯铵和安慰剂之前均接受了甲基东莨菪碱。相反，胆碱能拮抗剂东莨菪碱（0.5毫克）损害学习能力，而阿考氯铵和胆碱可逆转这种损害，且东莨菪碱造成的损害与受试者在安慰剂测试中的表现呈负相关；也就是说，“表现差”的受试者比“表现好”的受试者更容易受到胆碱能激动剂及其前体的增强作用以及胆碱能拮抗剂造成的损害的影响。
