Mohs R C, Davis K L
Life Sci. 1985 Jul 15;37(2):193-7. doi: 10.1016/0024-3205(85)90423-0.
In a previous study (1), 8 gm. of oral choline given in a single dose were found to partially reverse the amnestic and subjective effects of 0.43 mg of scopolamine. The present study determined whether similar effects could be produced by 14 gm of choline given in 4 divided doses over 24 hrs and whether choline's effects in either study were related to plasma choline concentration. Ten normal subjects were given memory tests on three separate days, once after receiving 14 gm choline and 0.35 mg scopolamine (Ch-Sc), once following placebo and scopolamine (Pl-Sc), and once following placebo and placebo (Pl-Pl). Scopolamine markedly impaired memory performance but there was no difference between the Ch-Sc and Pl-Sc conditions. Plasma choline levels were significantly elevated in the Ch-Sc condition of both the single dose and divided dose studies. There was no difference in levels between studies nor were differences in memory performance correlated with elevations in plasma choline. These results indicate that any enhancement of cholinergic activity due to increased dietary choline is transient and of small magnitude.
在之前的一项研究（1）中，发现单次口服8克胆碱可部分逆转0.43毫克东莨菪碱的记忆缺失和主观效应。本研究确定了在24小时内分4次给予14克胆碱是否能产生类似的效果，以及在这两项研究中胆碱的效果是否与血浆胆碱浓度有关。10名正常受试者在三个不同的日子接受记忆测试，一次是在接受14克胆碱和0.35毫克东莨菪碱后（胆碱-东莨菪碱组），一次是在接受安慰剂和东莨菪碱后（安慰剂-东莨菪碱组），还有一次是在接受安慰剂和安慰剂后（安慰剂-安慰剂组）。东莨菪碱显著损害记忆表现，但胆碱-东莨菪碱组和安慰剂-东莨菪碱组之间没有差异。在单次给药和分次给药研究的胆碱-东莨菪碱组中，血浆胆碱水平均显著升高。两项研究之间的水平没有差异，记忆表现的差异也与血浆胆碱升高无关。这些结果表明，由于饮食中胆碱增加而导致的胆碱能活性增强是短暂的且幅度较小。
