工程化贵金属纳米材料作为表面增强拉曼散射活性平台在癌症诊断中的最新进展。

Recent Advances in Engineered Noble Metal Nanomaterials as a Surface-Enhanced Raman Scattering Active Platform for Cancer Diagnostics.

机构信息

State Key Laboratory of Bioelectronics, National Demonstration Center for Experimental Biomedical Engineering Education, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.

出版信息

J Biomed Nanotechnol. 2022 Jan 1;18(1):1-23. doi: 10.1166/jbn.2022.3246.

DOI:10.1166/jbn.2022.3246

PMID:35180897

Abstract

Recently, noble metal nanomaterials have been extensively studied in the fields of biosensing, environmental catalysis, and cancer diagnosis and treatment, due to their excellent electrical conductivity, high surface area, and individual physical and optical properties. Early research on the surface-enhanced Raman scattering (SERS) effect was focused on the cognition of the SERS phenomenon and enhancing its sensitivity for single-molecule detection. With the development of nanomaterials and nanotechnology, the advances and applications based on SERS substrates have been accelerated. Among them, noble metal nanomaterials are mainly used as SERS-active substrates to enhance SERS signals owing to their compelling surface plasmon resonance (SPR) properties. This review provides recent advances, perspectives, and challenges in SERS assays based on engineered noble metal nanomaterials for early cancer diagnosis.

摘要

最近，由于贵金属纳米材料具有优异的导电性、高的比表面积以及独特的物理和光学性质，它们在生物传感、环境催化以及癌症诊断和治疗等领域得到了广泛的研究。早期对表面增强拉曼散射（SERS）效应的研究主要集中在对 SERS 现象的认知和提高其用于单分子检测的灵敏度上。随着纳米材料和纳米技术的发展，基于 SERS 衬底的进展和应用得到了加速。其中，贵金属纳米材料主要用作 SERS 活性衬底，以增强 SERS 信号，这是由于它们具有引人注目的表面等离子体共振（SPR）特性。本综述提供了基于工程贵金属纳米材料的用于早期癌症诊断的 SERS 分析的最新进展、观点和挑战。