Department of Obstetrics and Gynecology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, 102218, China.
Department of Reproductive Medicine, Shenyang 204 Hospital, Liaoning, 110000, China.
Taiwan J Obstet Gynecol. 2022 Jan;61(1):80-85. doi: 10.1016/j.tjog.2021.11.015.
To investigate the risk of occurrence of second primary malignancies (SPMs) in survivors of ovarian cancer (OC) using large data from the Surveillance, Epidemiology, and End Results (SEER) database.
Multiple primaries standardized incidence ratios (MP-SIRs) to calculate the risk of developing second primary malignancies after a diagnosis of ovarian cancer.
Of our included 59,880 women with OC, 3972 cases (6.6%) developed 4495 s primary malignancies over an average follow-up period of 114.39 (±102.66) months. Overall, the risk of occurrence of second primary malignancies after a diagnosis of OC was greater than what would be expected for a reference US population (SIR = 1.05, 95%CI = 1.02-1.08, p-value < 0.05). The occurrence of second myeloid malignancies and second thyroid cancer were most notable across our latency periods. Among the most significant second primary malignancies by latency were malignancies of the appendix (SIR = 14.04, 95%CI = 5.65-28.93, p-value <0.05) at 2-11 months, the small intestine (SIR = 3.15, 95%CI = 1.76-5.2, p-value <0.05) at 12-59 months, and the urinary bladder (SIR = 1.63, 95%CI = 1.3-2.02, p-value <0.05) after 10 years of an OC diagnosis.
Women with OC are at significant risk for the development of second primary malignancies across all sites, as compared to a reference US population, and may benefit from second primary malignancies site-specific screening post-diagnosis.
利用来自监测、流行病学和最终结果（SEER）数据库的大量数据，研究卵巢癌（OC）幸存者发生第二原发恶性肿瘤（SPM）的风险。
使用多原发标准化发病比（MP-SIR）来计算诊断为卵巢癌后发生第二原发恶性肿瘤的风险。
在我们纳入的 59880 名 OC 女性中，有 3972 例（6.6%）在平均 114.39（±102.66）个月的随访中发展为 4495 例第二原发恶性肿瘤。总体而言，OC 诊断后发生第二原发恶性肿瘤的风险高于美国参考人群（SIR=1.05，95%CI=1.02-1.08，p 值<0.05）。在潜伏期内，第二髓样恶性肿瘤和第二甲状腺癌的发生风险最为显著。在潜伏期内最显著的第二原发恶性肿瘤中，阑尾恶性肿瘤（SIR=14.04，95%CI=5.65-28.93，p 值<0.05）的发生风险最高，潜伏期为 2-11 个月，小肠恶性肿瘤（SIR=3.15，95%CI=1.76-5.2，p 值<0.05）的潜伏期为 12-59 个月，膀胱癌（SIR=1.63，95%CI=1.3-2.02，p 值<0.05）的潜伏期超过 10 年。
与美国参考人群相比，OC 女性发生所有部位第二原发恶性肿瘤的风险显著增加，因此在诊断后可能受益于第二原发恶性肿瘤特定部位的筛查。
