Study Group of Laser and Health Institute. São Paulo, SP, Brazil.
Graduate Program in Implantology, University of Santo Amaro, School of Dentistry. São Paulo, SP, Brazil.
Photodiagnosis Photodyn Ther. 2022 Mar;37:102678. doi: 10.1016/j.pdpdt.2021.102678. Epub 2021 Dec 8.
Opportunistic infections are widely described in patients with novel coronavirus disease 2019 (COVID-19); however, very few studies have addressed those affecting the oral cavity. Given the lack of information on the clinical presentations and the available treatment options, the present study aimed to show a case in which a combination of antimicrobial photodynamic therapy (aPDT) and photobiomodulation therapy (PBMT) was used for the management of two concomitant COVID-19-associated opportunistic oral infections (oral pseudomembranous candidiasis and recurrent herpes labialis). Within 7 days and without any systemic drug administration, all the lesions resolved completely, and the patient no longer reported oral pain or discomfort. According to the current case report and taking into consideration the significant gaps in the knowledge and understanding of COVID-19, this combination of phototherapy modalities seems to be a promising tool for managing viral and fungal opportunistic oral infections.
机会性感染在新型冠状病毒病 2019（COVID-19）患者中广泛描述；然而，很少有研究涉及口腔感染。鉴于缺乏有关临床表现和可用治疗选择的信息，本研究旨在展示一种情况下，联合使用抗菌光动力疗法（aPDT）和光生物调节疗法（PBMT）来治疗两种同时发生的 COVID-19 相关机会性口腔感染（口腔假膜性念珠菌病和复发性唇疱疹）。在 7 天内，且未进行任何全身药物治疗的情况下，所有病变完全消退，患者不再报告口腔疼痛或不适。根据目前的病例报告，并考虑到对 COVID-19 的认识和理解存在显著差距，这种光疗联合治疗方法似乎是治疗病毒和真菌性机会性口腔感染的有前途的工具。
