由红树林内生真菌 Pestalotiopsis sp. SAS4 产生的邻苯二甲酸代谢物。
Phthalide metabolites produced by mangrove endophytic fungus Pestalotiopsis sp. SAS4.
机构信息
Key Laboratory of Molecular Target and Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
出版信息
Magn Reson Chem. 2022 May;60(5):525-529. doi: 10.1002/mrc.5259. Epub 2022 Feb 27.
Two new phthalide derivatives (1-2) and four known phthalide compounds (3-6) were purified from the culture of a mangrove endophytic fungus Pestalotiopsis sp. SAS4. Their chemical structures were established by analyses of 1D and 2D nuclear magnetic resonance (NMR) and high resolution mass spectrometry (HR-MS) spectroscopic data. All of these compounds were evaluated in vitro for antibacterial, cytotoxicity, and resistance to hypoxic-ischemic injury activities.
从红树林内生真菌 Pestalotiopsis sp. SAS4 的培养物中分离得到了两个新的苯酞衍生物（1-2）和四个已知的苯酞类化合物（3-6）。通过 1D 和 2D 核磁共振（NMR）和高分辨率质谱（HR-MS）光谱数据分析确定了它们的化学结构。所有这些化合物都在体外进行了抗菌、细胞毒性和抗缺氧缺血损伤活性的评价。
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